Evidencia científica

  1. Chrousos GP, Gold PW. A healthy body in a healthy mind- and viceversa- the damaging power of uncontrollable stress. J Clin Endocr Metab 1998; 83: 1842-1845.
  2. Heijnen CJ. Who believes in communication. Brain Behav Imm 2000; 14: 2-9.
  3. OMahony, Palder SB, Mannick JA, et al. Depresion of cellular immunit y af ter multiple trauma in the absence of sepsis. J Trauma 1984; 24: 869-875.
  4. Abraham E. Host defense abnormalities af ter hemorrage, trauma, and burns. Critic Care Med 1989; 17: 934-939.
  5. Marshal GD, Agar wal SK, Lloyd C, et al. Cytokine dysregulation associated with exam stress in healthy medical students. Brain Behav Immun 1998; 19: 297-307.
  6. Connor TL, Leonard BE. Depression, stress, and immunological activation. The role of cytokines in depresive disorders. Life Sci 1998; 7: 583-606.
  7. Miller AH. Neuroendocrine and immune system interactions in stress and depression. Psychiatr Clin North Am 1998; 21: 443-463.
  8. Bushe-Kirsdbaum N. Preliminary evidence for herpes labialis recurrence following experimentally induced-disgust. Psychother Psychosom 2001; 70: 86-89.
  9. Miller ES, Klinger JC, Akin C, et al. Inhibition of murine splenic T lymphocyte proliferatión by 2-deoxy-d-glucose-induced metabolic stress. J Neuroimmunol 1994; 52: 165-173.
  10. Stowe RP, Pierson DL, Feeback DL, et al. Stress induced reactivation of Epstein Barr virus in astronauts. Neuroimmodulation 2000; 8: 51-85.
  11. Taylor GR, Konstantinova I, Sonnenfeld G, Jennings R . Changes in the immune system during spaceflight. Adv Space Biol Med 1997; 6: 1-32.
  12. Fitzgerald L. Exercise and the immune sytem. Immunol Today 1998; 9: 337-338.
  13. Tingate TR, Lugg DJ, Muller HK, Stowe RP, Pierson DL. Antartic isolation: immune and viral studies. Immunol Cell Biol 1997; 75: 275-283.
  14. Solomon GF, Sergerstrom CS, Grohr P, Kemmeny M, Fajey J. Shaking up: psychological and immunological changes after a natural disaster. Psychosom Med 1997; 59: 114-127.
  15. Kawamura M. Suppression of cellular immunit y in men with a past history of postraumatic disorder. Am J Psychol 2000; 158: 484-486.
  16. Paul WE, Seder RA. Lymphocytes responses and cytokines. Cell 1994; 76: 241-251.
  17. Arai KI, Miyajima LF, Miyatake S, et al. Cytokines: coordinators of immune and inflammatory responses. Annu Rev Biochem 1990; 59: 783-836.
  18. Dinarello CA. IL-1 and IL-1 antagonism. Blood 1991; 77: 1627.
  19. Akira S, Kisimoto T. IL-6 and NF-IL-6 in acute phase response and viral infection. Immunol Rev 1992; 127: 25-50.
  20. Trinchieri G. Interleukin 12: a proinflamatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Ann Rev Immunol 1995; 13: 251-276.
  21. Tracey KJ, Cerami A. Tumor necrosis factor: a pleotropic cytokine and therapeutic target. Ann Rev Immunol 1994; 4: 491-503.
  22. Standiford TJ. Anti-inflammatory cytokines and cytokine antagonists. Current Pharmac Des 2000; 6: 633-649.
  23. Doetze A, Satoquina J, Burchard G, et al. Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by Th3/tr1-t ype cytokines IL-10 and transforming growth factor -b but not by a Th1 to Th2 shif t. Intern Immunol 2000; 12: 623-630.
  24. Oberholzer C, Moldawer LL. Cytokine signaling-regulation of the immune response in normal and critically ill states. Crit Car Med 2000; 28: 4.
  25. Fernández-Botrán R, Sanders VM, Mossman TM, Vitetta ES. Lymphokine mediated regulation of the proliferative response of clone of T helper 1 and T helper 2 cells. J Exp Med 1988168: 543-558.
  26. Smith A. Interleukin 2. Ann Rev Immunol 1984; 2: 319-333.
  27. Gallin JY, Farber JM, Holland S, et al. Interferon-g in the management of infectious diseases. Ann Intern Med 1995; 123: 216-224.
  28. Paul WE. Interleukin 4: a protot ypic immunoregulatory lymphokine. Blood 1991; 77: 1859-1991.
  29. Fiorentino DF, Zlonik A, Vierra P, et al. IL-10 acts on the antigen presenting cells to inhibit cytokine productión by Th1 cells. J Immunol 1991; 146: 3444-3451.
  30. Ashwell JD, Lu FWM, Vacchio M. Glucocorticoids in T cell development and function. Annu Rev Immunol 2000; 18: 309-345.
  31. Berquist J, Tarkowski A, Ewing A, Ekman R . Catecolaminergic supression of immunocompetent cells. Immunol Today 1998; 19: 562-574.
  32. Mashkoor A, Choudhry N, Sarfraz A, et al. Prostaglandin E2 down-regulation of T cell IL-2 roduction is independent of IL-10 during Gram-negative sepsis. Immunol Lett 1999; 67: 125-130.
  33. Weigent DA, Blalock E. Interactions bet ween the neuroendocrine and immune systems: common hormones and receptors. Immunol Rev 1987; 100: 79-108.
  34. Van Dijk WC, Verbrugh HA, Van Rijswijk Ren Vos A, et al. Neutrophyl function, serum opsonic activit y, and delayed hypersensitivity in surgical patients. Surgery 1999; 92: 21-29.
  35. Goto S. Analysis of Th1 and Th2 cytokine production by peripheral blood mononuclear cells as a parameter of immunological dysfunction in advanced cancer patients. Cancer Immunol Immunoth 1999; 48: 435-449.
  36. Wilder RL, Elenkov IJ. Hormonal regulation of tumor necrosis factor-alpha, interleukin-12 and interleukin-10 production by activated macrophages. A disease-modifying mechanism in rheumatoid arthritis and systemic lupus erythematosus? Ann NY Acad Sci 1999; 876: 14-31.
  37. Krieglstein K. Synergy effects of cytokines lead to development of neurotrophic funtions. Ann Anat 1999; 181: 423-427.
  38. Sugita Y, Zhao B, Shankar P, et al. CNS interleukin 13 (IL-3) expression in antisense IL-3 trasgenic mice. J Neuropathol Exp Neurol 1999; 58: 480-486.
  39. Licinio J, Wong ML. The role of inflammatory mediators in the biology of major depression: central ner vous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neurodegeneracion. Mol Psychiatry 1999; 4: 317-321.
  40. Sanderson SJ. Interleukin 5, eosinophils and disease. Blood 1992; 79: 3101-3107.
  41. Keane RM, Birmingham W, Shatney CM, et al. Suppresor cell activit y af ter major injury: indirect and funcional assays. J Trauma 1982; 22: 770-776.
  42. Slifka MK, Whitton JL. Clinical implications of dysregulated cytokine production. J Mol Med 2000; 78: 74-80.
  43. Agar wal SK, Marshal GD. Glucocorticoid induced t ype-1/Type-2 cytokine alterations in humans a model for stress-related immune dysfuction. J Interf Cytokine Res 1998; 18: 1059-1068.
  44. Suffredini AF, Openheim JJ. New insights into the biology of the acute phase response. J Clin Immunol 1999; 4: 203-209.
  45. Malef yt RW, Haanen J, Spits H, et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991; 174: 915-924.
  46. Kox WJ, Bone RC, Krusch D, et al. Interferon gamma-1 b in the treatment of compensatory anti-inflammatory response syndrome. A new approach. Arch Intern Med 1997; 157: 389-393.
  47. Elenkov IJ, Hasko G, Kovacs KJ, et al. Modulation of lipopolysacharide-induced tumor necrosis factor-alpha production by selective alpha- and beta adrenergic drugs in mice. J Neuroimmunol 1995; 61: 123-131.
  48. Rook GAW, Hernández-Pando R . The pathogenesis of tuberculosis. Annu Rev Microbiol 1996;50: 259-284.
  49. Yamamura M, Uyemura K, Deans RJ, et al. Defining protective response to pathogens: cytokine profiles in leprosy lesions. Science 1991; 254: 277-282.
  50. Fitzgerald TJ. The Th1/Th2-like switch in syphilitic infection: is it detrimental? Infect Immunol 1992; 60: 3475-3479.
  51. Heinzel FP, Sadick MD, Holaday BJ, et al. Reciprocal expression of interferon-gamma or interleukin 4 during resolution or progression of murine lehismaniasis. J Exp Med 1989; 169: 59-72.
  52. Monroy FP. Cold stress-induced modulation of inflammatory responses and intracerebral cytokine mRNA expression in acute murine toxoplasmosis. J Parasitol 1999; 85: 878-883.
  53. Mehta SK, Stowe RP, Feiveson AH, Tyring ST, Pierson DL. Reactivation and shedding of cytomegalovirus in astronauts during spaceflight. J Infect Dis 2000; 6: 1761-1767.
  54. Bonneau RH, Brehm MA, Kern AM. The impact of psychological stress on the efficacy of antiviral-adoptive
  55. immunotherapy in an immunocompromised host. J Neuroimmunol 1997; 2: 19-33.
  56. Dairaghi DJ, Greaves DR, Schall TD. Abduction of chemoquines elements by herpes viruses. Sem Virol 1998; 8: 377-385.
  57. Choi JK, Means RE, Da mania B, et al. Molecular pyracy of sarcoma Kapossi´s associatedd herpes virus. Cytok Grow Fact Rev 2001; 12: 24-27.
  58. Heis LJ, Hinde SL. Susceptibilit y of citomegalovirus infection may be dependent of cytokine production by the host. J Inv Med 2001; 49: 5-16.
  59. Rook G. Th1-Th2 switch and loss of CD4 cells in chronic infections; an immunoendocrinogical hypothesis not exclusive to VIH. Immunol Today 1997; 14: 568-569.
  60. Howland LC, Gortmaker SL, Mofenson LM, et al. Effects of negative life events on immuno suppression in children and youth infected by the human inmunodeficiency virus type 1. Pediatrics 2000; 106: 540-546.
  61. Leserman J, Petitto JM, Golden RN, et al. Impact of stressful life events, depression, social support, coping and cortisol progression to AIDS. Am J Psychol 2000; 157: 1221-1228.
  62. Ishiagami T. The influence of psychic acts on the progress of pulmonary tuberculosis. Am Rev TBC 1919; 2: 470-484.
  63. Clarke ERJr, Zahn DW, Holmes TH. The relationship of stress, adrenocortical function, and tuberculosis. Am Rev Tuberc 1954; 69: 351-359.
  64. Restrepo A, Ramírez A, Ulloa A, et al. Factores psicosociales y tuberculosis pulmonar en pacientes de bajo nivel socioeconómico. Av Med Soc 1994; 4: 34-37.
  65. Pérez-Guzmán C, Vargas MH, Torres Cruz A, Villarreal-Velarde H. Does aging modif y tuberculosis? A meta analysis review. Chest 2001; 116: 961.
  66. Elenkov IJ, Papanicolaou DA, Wilder RL, et al. Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications. Proc Assoc Am Phys 1996; 5: 374-381.
  67. Evengard B, Schacterle RS, Komaroff AL.Chronic fatigue syndrome: New insights and old ignorance. J Intern Med 1999; 246: 45-49.
  68. Levenstein S. Stress and peptic ulcer. Life beyond Helicobacter pylori. Br Med J 1998; 318: 538-541.
  69. Kiecolt-Glaser JK, Glaser R . Psychoneuroimmunology and immunotoxicology: implications for carcinogenesis. Psychol Med 1999; 61: 271-272.
  70. Pearce AK, Humphrey TC. Integrating stress-response and cell cyclo. Trends Cell Biol 200111: 426-433.
  71. Yudkin JS, Kumari M, Humphries SE, et al. Inflammation, obesit y, stress, and coronary hearth disease: is interleukin-6 the link? Atherosclerosis 2000; 148: 209-214.
  72. Corral LG, Kalan G. Immunomodulation by thalidomide and thalidomide analogs. Ann Rheum Dis 1999; 58: 71-113.
  73. Hart DN. Dendritic cells: unique leucocyte population which control the primary immune response. Blood 1998; 90: 3245-3287.
  74. Galluci S, Matzinger P. Danger signal: SOS to the immune system. Curr Opin Immunol 2001; 13: 114-119.
  75. Kronin V, Hochrein H, Shortman K, et al. Regulation of T cell cytokine production by dendritic cells. Immunol Cell Biol 2000; 78: 214-223.
  76. ALILSA, K. et al. Reconsidering the refractory period: An exploratory study of women’s post-orgasmic experiences. The canadian journal of human sexuality. Vol 18 (3). 2009. 127-135
  77. ARCK, P.C., B. HANDJISKI, E.M. PETERS, et al. Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammation events via neuropeptide substance P-dependent pathways. 2003. Am. J. Pathol. 62: 803-814
  78. BIRKETVEDT, G., J. FLORHOLMEN, J. SUNDSFJORD, et al. Behavioral and neuroendocrine characteristics of the night-eating syndrome. 1999. JAMA 282: 657–663
  79. BJÖRNTORP, P. Do stress reactions cause abdominal obesity and comorbidities? 2001. Obesity Reviews 2 (2): 73-86
  80. BLACK, H.P., L.D. GARBUTT. Stress, inflammation and cardiovascular disease, 2002. J. Psychosom. Res. 52 (1): 1-23
  81. CATLEY, D., A.T. KAELL, C. KIRSCHBAUM, & A.A. STONE. Naturalistic evaluation of cortisol secretion in persons with fibromyalgia and rheumatoid arthritis. 2002. Arthritis Care Res. 13 (1): 5-61
  82. DALLMAN, M.F., N.C. PECORARO, S.E. LA FLEUR, et al. Glucocorticoids, chronic stress, and obesity. 2006. Prog. Brain Res. 153: 75-105.
  83. EPEL, S.E., E.H. BLACKBURN, J. LIN. et al. Accelerated telomere shortening in response to life stress. 2004. PNAS 101 (49): 17312-17315
  84. EVOLATHI, A., M. HULTCRANTZ, A. COLLINS. Women’s work stress and cortisol levels: A longitudinal study of the association between the psychosocial work environment and serum cortisol. 2006. J. Psychosom. Res. 61 (5): 645-652
  85. FRANCESCHI, C., F. OLIVIERI, F. MARCHEGIANI, et al. Genes involved in inmune response/inflammation, IGFI/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. 2005. Mechanisms of Ageing and Development 126 (2): 351-361.
  86. HOSOI, J. Stress and the skin. 2006. Int. J. Cosmetic Science 28: 243-246
  87. LA FLEUR, E.S., H. HOUSHYAR, M. ROY & M.F. DALLMAN. Choice of lard, but not total lard calories, damps adrenocorticotropin responses to restraint. Endocrinology 146 (5): 2193-2199
  88. Levin R. Revisiting post-ejaculation refractory time –What we know and what we do not know in males and in females. Journal of sexual medicine. 2009 september, 6(9). 2376-2389
  89. MARX, J. Inflammation and Cancer: The link grows stronger. 2004. Science 306 (5698): 966-968
  90. MASTORAKOS, G., M. PAVLATOU. Exercise as a stress model and the interplay between the hypothalamus-pituitary-adrenal and the hypothalamus-pituitary-thyroid Axes. 2005. Horm. Metab. Res. 37:577-584
  91. PECORARO, N., F. REYES, F. GOMEZ, et al. Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress. 2004. Endocrinology 145 (8): 3754-3762
  92. SAINT MEZARD, P., C. CHAVAGNAC, S. BOSSET, et al. Psychological stress exerts an adjuvant effect on skin dendritic cell function in vivo. 2003. The J. Immunol. 171: 4073-4080
  93. STUNKARD, A.J., W.J. GRACE, H.G. WOLFF. The night eating syndrome: a pattern of food intake in certain obese patients. 1955. Am.J. Med 19: 78-86
  94. TENNANT, K.V. The powerful Impact of Stress and Calm on Health Behaviour and Learning. www.newhorizons.org
  95. Food and pain: Should we be more interested in what our patients eat?. PAIN. 2007. Rae Frances Bell Urquiaga and Lieghton. 2000; Lastra, Villegas. 2005
  96. Muller et al. 2001; Beauchamp et al. 2005.
  97. Carrillo and Benítez. 2000; Acheson et al. 2004; Norager et al. 2006; Focking et al. 2005;Tucker et al. 2006
  98. Harris et al. 2003; Bressler, 2006; Murray, 2006
  99. World Health Organization, “Diet, nutrition and the prevention of chronic disease”, Geneva, 2003
  100. Flórez J. El tratamiento farmacológico del dolor. Ars Medica; p. 89. 2007
  101. Mather L. Principles of treatment and management, Unit 3: Pharmacological Management. MSc in pain management. University of Sydney.
  102. Mather LE, Smith MT. Opioid analgesics – clinical pharmacology and adverse effects. In, Opioids in Pain Control – Basic and Clinical Aspects. Ed, C Stein. Cambridge University Press, 1997.
  103. Panus PC, Katzung B, Jobst EE, Tinsley SL, Masters SB, Trevor AJ. Pharmacology for the Physical Therapist. McGraw Hill Medical. 2009
  104. Sluka KA. Central mechanisms involved in pain processing. In: Sluka KA, editor. Mechanisms and management of pain for the physical therapist. Seattle: IASP press; p. 242-250. 2009
  105. Kiecolt-Glaser et al., 1995; Marucha et al., 1998; Padgett et al., 1998; Denda et al., 2000; Garg et al., 2001; Altemus et al., 2001; Kiecolt-Glaser et al., 2005; Christian et al., 2006
  106. Silvia Gariboldi italian Mucosal Immunity Laboratory, Department of Human Morphology and Biomedical Sciences ‘‘Citta` Studi’’, Universita` degli Studi di Milano, via Mangiagalli 31, 20133 Milano, Italy
  107. Tim Willinger, Tom Freeman, Hitoshi Hasegawa, Andrew J. McMichael and Margaret F. C. Callan, Molecular Signatures Distinguish Human Central Memory from Effector Memory CD8 T Cell Subsets1, J. Immunol. 2005;175;5895-5903 http://www.jimmunol.org/cgi/content/full/175/9/5895
  108. Jacques D. La Micro-Immunoterapia applicata alle infezioni da Papillomavirus (HPV) – Il ruolo del 2L®PAPI. Cahiers de Biothérapie 2008; 3 (anno XVI): 29-34.
  109. Jenaer M., Henry MF., Garcia A., Marichal B. Evaluation of 2LHERP in preventing recurrences of genital herpes. Bristish Homeopathic Journal (2000); 89: 174-177.
  110. Santi C., Mor, C. The Micro-Immunotherapy as a complementary Cancer Treatment: a study on Metastasic Patients. Journal of Tumor Marker Oncology, Primavera 2003, Nº 2 (Volume 18): 105-109.
  111. Endocrinología del Sueño (2007). Gabriela Barrueto, Carolina Gómez, Cecilia Gómez , Rocío Montoya
  112. Endocrinología del  Sueño:  Felipe  Albornoz (2007).  Loreto  Inda  Francisca  Larée, Macarena Parra, Constanza Pineda
  113. Obal F Jr, Krueger JM. Biochemical regulation of non-rapid-eyemovement sleep. Frontiers Biosci 2003; 8: 520-50.
  114. Alam N, McGinty D, Imeri L. Effects of interleukin-1 beta on sleep and wake-related preoptic anterior hypothalamic neurons in unrestrained rats. Sleep 2001; 24: 59-65.
  115. Krueger JM, Majde JA. Humoral links between sleep and the immune system: research issues. Ann N Y Acad Sci 2003; 992: 9
  116. Larson SJ. Behavioral and motivational effects of immune-system activation.J Gen Psychol 2002; 129: 401-14.
  117. Obal F Jr, Krueger JM. Biochemical regulation of non-rapid-eyemovement sleep. Frontiers Biosci 2003; 8: 520-50.
  118. Alam N, McGinty D, Imeri L. Effects of interleukin-1 beta on sleep and wake-related preoptic anterior hypothalamic neurons in unrestrained rats. Sleep 2001; 24: 59-65.
  119. Morgan PJ, Barrett P, Howell HE, Helliwell R. Melatonin receptors: localization, molecular pharmacology and physiologic significance. Neurochem Int 1994; 24: 101-46.
  120. Bettahi I, Guerrero JM, Reiter RJ, Osuna C. Physiological concentrations of melatonin inhibit the norepinephrine-induced activation of prostaglandin E2 and cyclic AMP production in rat hypothalamus: a mechanism involving inhibition of nitric oxide synthase. J Pineal Res 1998; 25: 34-40.
  121. Lautenbacher S, Kundermann B, Krieg JC. Sleep deprivation and pain perception. Sleep Med Rev 2006.
  122. Arend WP, Gabay C. Cytokines in the rheumatic diseases. Rheum Dis Clin North Am 2004;30:41-67 v-vi.
  123. Opp MR, Born J, Irwin M. Sleep and the immune system. Psychoneuroimmunology 2006:539-78.
  124. Maier SF. Bi-directional immune-brain communication: implications for understanding stress, pain, and cognition. Brain Behav Immun. 2003;17:69-85. [PubMed]
  125. Lentz MJ, Landis CA, Rothermel J, Shaver JL. Effects of selective slow wave sleep disruption on musculoskeletal pain and fatigue in middle aged women. J Rheumatol. 1999;26:1586-1592. [PubMed]
  126. Watkins LR, Milligan ED, Maier SF. Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol. 2003;521:1-21. [PubMed]
  127. Ranjit N, Diez-Roux AV, Shea S, et al. Psychosocial factors and inflammation in the multi-ethnic study of atherosclerosis. Arch Intern Med. 2007;167:174-181.
  128. Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004;130:601-630.
  129. Hirano D, Nagashima M, Ogawa R, Yoshino S. Serum levels of interleukin 6 and stress related substances indicate mental stress condition in patients with rheumatoid arthritis. J Rheumatol. 2001;28:490-495.
  130. Davis MC, Zautra AJ, Younger J, et al. Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis. Brain Behav Immun. 2008;22:24-32.
  131. Motivala SJ, Khanna D, FitzGerald J, Irwin MR. Stress activation of cellular markers of inflammation in rheumatoid arthritis: protective effects of tumor necrosis factor alpha antagonists. Arthritis Rheum. 2008;58:376-383.
  132. Pace TW, Mletzko TC, Alagbe O, et al. Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am J Psychiatry. 2006;163:1630-1633. [PubMed]
  133. Irwin M, Wang M, Ribiero D, et al. Sleep loss activates cellular inflammatory signaling. Biol Psychiatry. 2008 Jun 16; [Epub ahead of print]
  134. Redwine L, Hauger RL, Gillin JC, Irwin M. Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab. 2000;85:3597-3603.
  135. Redwine L, Dang J, Hall M, Irwin M. Disordered sleep, nocturnal cytokines, and immunity in alcoholics. Psychosom Med. 2003;65:75- 85.
  136. Irwin MR, Wang M, Campomayor CO, et al. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch Intern Med. 2006;166:1756-1762.
  137. Irwin M, Rinetti G, Redwine L, et al. Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics. Brain Behav Immun. 2004;18:349-360.
  138. Vgontzas AN, Zoumakis M, Bixler EO, et al. Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: physiologic and therapeutic implications. J Clin Endocrinol Metab. 2003;88:2087-2095.
  139. Collado-Hidalgo A, Bower JE, Ganz PA, et al. Inflammatory biomarkers for persistent fatigue in breast cancer survivors. Clin Cancer Res. 2006;12:2759-2766.
  140. Bower JE, Ganz PA, Aziz N, Fahey JL. Fatigue and proinflammatory cytokine activity in breast cancer survivors. Psychosom Med. 2002;64:604-611.
  141. Drewes AM. Pain and sleep disturbances with special reference to fibromyalgia and rheumatoid arthritis. Rheumatology (Oxford) 1999;38:1035-8.
  142. Delgado JA, Murali G, Goldberg R. Sleep disorders in fibromyalgia. Sleep 2004;27:A339
  143. Khan SA, Goldberg R, Haber A. Sleep disorders in fibromyalgia. Sleep 2005;28:A290
  144. Straub RH, Dhabhar FS, Bijlsma JW, Cutolo M. How psychological stress via hormones and nerve fibers may exacerbate rheumatoid arthritis. Arthritis Rheum. 2005;52:16-26
  145. Zautra AJ, Yocum DC, Villanueva I, et al. Immune activation and depression in women with rheumatoid arthritis. J Rheumatol. 2004;31:457-463.
  146. Feldmann M, Maini RN. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol. 2001;19:163-196.
  147. Feldmann M, Maini RN. Anti-TNF alpha therapy of rheumatoid arthritis:what have we learned? Annu Rev Immunol. 2001;19:163-196. [PubMed]
  148. Charles P, Elliott MJ, Davis D, et al. Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-αlpha therapy in rheumatoid arthritis. J Immunol. 1999;163:1521-1528. [PubMed]
  149. Elliott MJ, Maini RN, Feldmann M, et al. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha. Arthritis Rheum. 1993;36:1681-1690. [PubMed]
  150. Zamarron F, Maceiras F, Mera A, Gomez-Reino JJ. Effects of the first infliximab infusion on sleep and alertness in patients with active rheumatoid arthritis. Ann Rheum Dis. 2004;63:88-90.
  151. Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y AcadSci. 2001;933:222-234.
  152. Maier SF, Watkins LR. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev. 1998;105:83-107. [PubMed]
  153. Larson SJ. Behavioral and motivational effects of immune-system activation. J Gen Psychol. 2002;129:401-14. [PubMed]
  154. Reichenberg A, Yirmiya R, Schuld A, et al. Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry. 2001;58:445-452. [PubMed]
  155. Spath-Schwalbe E, Hansen K, Schmidt F, et al. Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men. J Clin Endocrinol Metab. 1998;83:1573-1579.
  156. Mullington J, Korth C, Hermann DM, et al. Dose-dependent effects of endotoxin on human sleep. Am J Physiol Regul Integr Comp Physiol. 2000;278:947-955. 1
  157. Zamarron F, Maceiras F, Mera A, Gomez-Reino JJ. Effects of the first infliximab infusion on sleep and alertness in patients with active rheumatoid arthritis. Ann Rheum Dis. 2004;63:88-90.
  158. Randomized controlled trials. Arthritis Rheum. 2002;47:291-302. [PubMed]
  159. Dixon KE, Keefe FJ, Scipio CD, et al. Psychological interventions for arthritis pain management in adults: a meta-analysis. Health Psychol. 2007;26:241-250. [PubMed]
  160. Matsuzaki T, Nakajima A, Ishigami S, et al. Mirthful laughter differentially affects serum pro- and anti-inflammatory cytokine levels depending on the level of disease activity in patients with rheumatoid arthritis. Rheumatology. 2006;45:182-186. [PubMed]
  161. Zautra AJ, Davis MC, Reich JW, et al. Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression. J Consult Clin Psychol. 2008;76:408-421. [PubMed]
  162. Austin, J.L., Cómo hacer cosas con palabras, Barcelona, Paidós 1971. Bateson, G., Steps to an ecology of mind, Nueva York, Ballantine Books, 1978. Beyebach, M., 24 Ideas para una terapia breve, Barcelona, Herder 2006. Ceberio M., Watzlawick P., La construcción del universo, Barcelona, Herder, 1998 Elster. Ulysses and the Sirens, Cambridge: Cambridge University Press, 1979. Fisch R., J.H. Weakland, L. Segal, La táctica del cambio, Barcelona, Herder 1984.
  163. Fisch R., Schlanger K., Cambiando lo incambiable, Herder, 2002.
  164. Foerster, .von, las semillas de la cibernética, Gedisa, Barcelona 1991.
  165. Glasersfeld, E. Von, Introducción al constructivismo Radical, En Watzlawick, P. La realidad inventada. Gedisa, Barcelona 1988.
  166. Kant,I., Critica de la razón pura, Tecnos, Madrid 2002
  167. Bateson,G., Steps Ecology of Mind, Nueva York: Ballantine Books, 1978 Nardone, G. Watzlawick P., El arte del cambio, Barcelona: Herder 1992
  168. Nardone, G., Miedo, pánico y fobias, Barcelona, Herder, 2002),
  169. Nardone G., Balbi E., Surcar el mar sin que el cielo lo sepa, Barcelona, Herder, 2009).
  170. Fiorenza, A., La intervención estratégica en contextos educativos, Barcelona, Herder 2004)
  171. Nardone, G., Psicosoluciones, Barcelona, Herder 2002). Nardone, G., El arte de la estratagema, Barcelona, RBA, 2004). Pascal, B., Pensamientos, Madrid, Espasa-Calpe, 2001.
  172. Rodríguez J.L, Venero M., Terapia Familiar Breve. Madrid, CCS 2006).
  173. Russell, B., The philosophy of B Rusell, Northwestern University, 1940.
  174. Watzlawick ,  Beavin,  J  H.Jackson,  D.D.,  Teoría  de  la  comunicación  humana, Barcelona, Herder, 1981).
  175. Weakland, J.H., Fisch, R., Cambio: formación y solución de los problemas humanos, Barcelona, Hereder, 1976).
  176. Watzlawick P., La realidad inventada., Gedisa, Barcelona 1989.
  177. Watzlawick P., El lenguaje del cambio, Nueva técnica de la comunicación terapéutica, Barcelona, Herder, 1989.
  178. Valenti G et al., 1984 Delayed LH response to GnRH in some hypotiroid women
  179. Honbo KS et al., 1978 Delayed LH response, may be PRL increased. TRH increasing TSH and PRL secretion. Galactorrea may occur.
  180. Krassas GE et al., 1999 Hypotiroidism results in changes in cycle lenght and amount of bleeding, secondary to anovulation. 171 hypothyroid women, 23% presented irregular cycles compared 8% in controls; 17 had oligomenorrhea, 6 hipomenorrhea, 5 amenorrhea y 12 hypermenorrhea/menorrhagia.
  181. Joshy et al., 1993 68% of hypotiroid women  had menstrual irregularities, compared with only 12% in controls.
  182. Wajner, S.M. et al. 2011. The Journal of Clinical Investigation 121 (5):1834-1845.
  183. Thyroid peroxidase gene expression is induced by lipopolysaccharide involving nuclear factor (NF)-κB p65 subunit phosphorylation. Nazar M, Nicola JP, Vélez ML, Pellizas CG, Masini-Repiso AM. Endocrinology. 2012 Dec;153(12):6114-25. doi: 10.1210/en.2012-1567. Epub 2012 Oct 12.
  184. Autoimmune thyroid diseases and coeliac disease. Sategna-Guidetti C, Bruno M, Mazza E, Carlino A, Predebon S, Tagliabue M, Brossa C. Eur J Gastroenterol Hepatol. 1998 Nov;10(11):927-31.
  185. Risk factors for and prevalence of thyroid disorders in a cross-sectional study among healthy female relatives of patients with autoimmune thyroid disease. Strieder TG, Prummel MF, Tijssen JG, Endert E, Wiersinga WM. Clin Endocrinol (Oxf). 2003 Sep;59(3):396-401.
  186. Viruses and thyroiditis: an update. Desailloud R, Hober D. Virol J. 2009 Jan 12;6:5. doi: 10.1186/1743-422X-6-5.
  187. Atrophic body gastritis in patients with autoimmune thyroid disease: an underdiagnosed association. Arch Intern Med. 1999 Aug 9-23;159(15):1726-30. Centanni M, Marignani M, Gargano L, Corleto VD, Casini A, Delle Fave G, Andreoli M, Annibale B.
  188. Is bile flow reduced in patients with hypothyroidism? Laukkarinen J, Sand J, Saaristo R, Salmi J, Turjanmaa V, Vehkalahti P, Nordback I. Surgery. 2003 Mar;133(3):288-93.
  189. Aporte óptimo de macronutrientes (carbohidratos, proteínas, grasas). (Catherine M. Gordon, 2010
  190. 1 gramo al día Acetyl-L-Carnitina (A. D. Genazzani et al. 2011
  191. (S Melmed et al. 2011
  192. Ursula B. Kaiser, 2012
  193. Rev Méd Chile 2008; 136: 367-375 . Enfermedad inflamatoria intestinal: Una mirada inmunológica
  194. Inflammatory bowel diseases: An immunological approach . Sofía E Sepúlveda1a, Caroll J Beltrán1,2b, Alexis Peralta1c, Paola Rivas1d, Néstor Rojas1d, Carolina Figueroa3, Rodrigo Quera4,5, Marcela A. Hermoso1e.Curr Pharm Des. 2009;15(13):1528-36
  195. The gut microbiota in inflammatory bowel disease. Macfarlane GT, Blackett KL, Nakayama T, Steed H, Macfarlane S. Am J Gastroenterol. 2009 May;104(5):1162-9. Epub 2009 Mar 24.
  196. The vexed relationship between Clostridium difficile and inflammatory bowel disease: an assessment of carriage in an outpatient setting among patients in remission. Clayton EM, Rea MC, Shanahan F, Quigley EM, Kiely B, Hill C, Ross RP.
  197. CURIOSO WH,DONAIRES N, BACILIO C, GANOZA C, LEÓN BARúA R. Prevalence and relation of dys- pepsia to irritable bowel syndrome in a native com- munity of the Peruvian jungle. Rev Gastroenterol Peru. 2002;22(2):129-40
  198. ORTIZ L et al Hipótesis inmune del síndrome del in- testino irritable. Primera parte: papel de los linfocitos y mastocitos Rev. Esp. Enferm. 2010; 102 : 11.
  199. SPILLER RC, JENKINS D, THORNLEY JP, et al. In- creased rectal mucosal enteroendocrine cells, T lym- phocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut
  200. 2000;47:804-811.
  201. KIRSCH R, RIDDELL RH. Histopathological al- terations in irritable bowel syndrome. Mod Pathol. 2006;19(12):1638-45.
  202. BARBARA G, STANGHELLINI V, DE GIORGIO R, et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syn- drome. Gastroenterology 2004;126:693-702.
  203. CHADWICK V, CHEN W, SHU D, et al. Activation of the mucosal immune system in irritable bowel syn- drome. Gastroenterology 2002;122:1778-1783.
  204. PICHE T, SAINT-PAUL MC, DAINESE R, et al. Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syn- drome. Gut. 2008;57:468
  205. O’SULLIVAN M, CALYTON N, BRESLIN NP, et al. In- creased mast cells in the irritable bowel syndrome. Neurogastronterol Motil 2000;12:449-457
  206. Kim HS, Lim JH, Park H, Lee SI.Incrased immuno- endocrine cells in intestinal mucosa of postinfectious irritable bowel syndrome patients 3 years after acute Shigella infection–an observation in a small case control study. Yonsei Med J. 2010 31;51(1): 45-51
  207. FORD AC, TALLEY NJ..Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review. J Gastroenterol. 2011;46(4):421-31
  208. PICHE T, SAINT-PAUL MC Mast cells and cellular- ity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome. Gut. 2008;57(4):468-73.
  209. LEE, K. J., KIM, Y. B., KIM, J. H., KWON, H. C., KIM, D. K. AND CHO, S. W. , The alteration of enterochromaf- fin cell, mast cell, and lamina propria T lymphocyte numbers in irritable bowel syndrome and its relation- ship with psychological factors.
  210. Journal of Gastroen- terology and Hepatology,2008. 23: 1689-1694.
  211. Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 2007;132:397-414
  212. Geeraerts B, Van OL, Boesmans W, Vos R, et al. Influence of acute tryptophan depletion on gastric sensorimotor function in humans. Am J Physiol Gastrointest Liver Physiol. 2011;300:G228- G235
  213. Tack J, Broekaert D, Corsetti M, et al. Influence of acute serotonin reuptake inhibition on colonic sensorimotor function in man. Aliment Pharmacol Ther. 2006;23:265-274
  214. Janssen P, Van Oudenhove L, Casteels C, et al. The effects of acute citalopram dosing on gastric motor function and nutrient tolerance in healthy volunteers. Aliment Pharmacol Ther. 2011;33:395-402
  215. Coates MD, Mahoney CR, Linden DR, et al. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrom Gastroenterology. 2004;126:1657-1664
  216. Camilleri M, Andrews CN, Bharucha AE, et al. Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. Gastroenterology. 2007;132:17-25
  217. Bearcroft CP, Perrett D, Farthing MJ. Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut. 1998;42:42-46
  218. Dunlop SP, Coleman NS, Blackshaw E, et al. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. Clin Gastroenterol Hepatol. 2005;3:349-357
  219. Atkinson W, Lockhart S, Whorwell PJ, et al. Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome. Gastroenterology. 2006;130:34-43
  220. Liu Q, Yang Q, Sun W, et al. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. J Pharmaco Exp Ther. 2008;325:47-55
  221. Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol Motil. 2011;23:193-200
  222. Brown P, Jackson J, Shi Z-C. LX1031: a new approach for managing irritable bowel syndrome. Gastroenterology. 2009;136(Suppl 1):A237;(abstract)
  223. Brown PM, Drossman DA, Wood AJJ, et al. The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome. Gastroenterology 2011;141:507-516
  224. Thumshirn M, Coulie B, Camilleri M, et al. Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2000;14:869-878
  225. Bharucha AE, Camilleri M, Haydock S, et al. Effects of a serotonin 5-HT(4) receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans. Gut. 2000;47:667-674
  226. 2005 Mar;128(3):541-51. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. O’Mahony L, McCarthy J, Kelly P, Hurley G, Luo F, Chen K, O’Sullivan GC, Kiely B, Collins JK, Shanahan F, Quigley EM.
  227. Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland .demonstrated an abnormal IL-10/IL-12 ratio in stimulated peripheral blood mononuclear cells (PBMCs), indicating a proinflammatory, Th-1 state.
  228. 2007 Mar;132(3):913-20. Epub 2007 Jan 26 Immune activation in patients with irritable bowel syndrome. Liebregts T, Adam B, Bredack C, Röth A, Heinzel S, Lester S, Downie-Doyle S, Smith E, Drew P, Talley NJ, Holtmann G.
  229. Department of Gastroenterology and Hepatology, University of Adelaide, Royal Adelaide Hospital, South Australia, Australia. showed an enhanced proinflammatory cytokine release (TNF-α, IL-1β, IL-6) in LPS stimulated PBMCs from IBS patients
  230. 2006 Feb;130(2):304-11. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential
  231. biomarker? Dinan TG, Quigley EM, Ahmed SM, Scully P, O’Brien S, O’Mahony L, O’Mahony S, Shanahan F, Keeling PW.
  232. Following CRH infusion, an exaggerated release of both ACTH and cortisol was observed in patients with IBS. There was a significant correlation between the
  233. ACTH response (deltaACTH) and the IL-6 levels. A similar relationship existed between the deltaACTH/deltacortisol ratio and the IL-6 levels. …plasma proinflammatory cytokines IL-6, IL-6R, and IL-8 were elevated in IBS and accompanied by overactivation of the HPA axis.
  234. The Lancet, Volume 361, Issue 9373, Pages 1923 – 1924, 7 June 2003 doi:10.1016/S0140-6736(03)13599-4Cite or Link Using DOI Cholinergic denervation in diverticular disease Tonia M Young-Fadok a, Gianrico Farrugia b
  235. J Clin Invest. 2007 Mar;117(3):636-47. Epub 2007 Feb 15. Role for protease activity in visceral pain in irritable bowel syndrome. Cenac N, Andrews CN, Holzhausen M, Chapman K, Cottrell G, Andrade-Gordon P, Steinhoff M, Barbara G,
  236. Beck P, Bunnett NW, Sharkey KA, Ferraz JG, Shaffer E, Vergnolle N.
  237. 2004 Mar;126(3):693-702 Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, Pasquinelli G, Morselli-Labate AM, Grady EF, Bunnett NW, Collins SM, Corinaldesi R.
  238. Klocker J, Perkmann R, Klein-Weigel P, et al. Continuous administration of heparin in patients with deep vein thrombosis can increase plasma levels of diamine oxidase. Vascul Pharmacol 2004;40:293-300
  239. Martner-Hewes PM, Hunt IF, Murphy NJ, Swendseid ME, Settlage RH. Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers. Am J Clin Nutr 1986;44:907-13
  240. Johnston CS. The antihistamine action of ascorbic acid. Subcell Biochem 1996;25:189-213.
  241. DiSilvestro RA, Jones AA, Smith D, Wildman R. Plasma diamine oxidase activities in renal dialysis patients, a human with spontaneous copper deficiency and marginally copper deficient rats. Clin Biochem 1997;30:559-63.
  242. Kehoe CA, Faughnan MS, Gilmore WS, Coulter JS, Howard AN, Strain JJ. Plasma diamino
  243. oxidase activity is greater in copper-adequate than copper-marginal or copper deficient rats.
  244. J Nutr 2000;130:30-3
  245. Supplement: Molecular Biomarkers of Copper Homeostasis Manuel Olivares, Marco A Méndez, Pablo A Astudillo, and Fernando Pizarro. Present situation of biomarkers for copper status Am J Clin Nutr September 2008 88: 859S-862S
  246. Anand, ,  Sundaram,  C.,  Jhurani,  S.,  Kunnumakkara,  A.B.,  and  Aggarwal,  B.B.  (2008).  Curcumin  and  cancer:  an  “old-‐age”  disease  with  an  “age-‐old”  soluDon.  Cancer  LeF  267,  133-‐164
  247. desmielinización observada en los pacientes que sufren esclerosis múltiple (Zappulla et al, 2002; Huszty Z. et al, 2004
  248. Adapted from Neubronner et al. Enhanced increase of omega-3 index in response to longterm n-3 fatty acid supplementation from triacylglycerides versus ethyl esters Eur J Clin
  249. Nutr 65 (2010) 247-254.
  250. Bioavailability of marine n-3 fatty acid formulations. Prostaglandins, leukotrienes and essential fatty acids 83 (2010) 137-141 Elsevier J.Dyerberg, P.Madsen, J.M.Moller, I. Aardestrup, E.B. Schmidt
  251. Schuchardt et at. lipids in health and disease 2011 10:145 Jan Philipp Schuchardt, Inga Schneider, Henrike Meyer, Juliane neubornner, Clemens Von Schacky and Anders Hahn
  252. The role of n-3 fatty acids in gestation and parturition Allen K.G.D. & HarrisM.A.(2001) Exp Biol Med 226: 498-606
  253. Sadovsky Y et al (2000) Am J Obstet Gynecol 182:370-376
  254. Reece MS et al (1996) Prost Leukotr Esse.FA 55:303-307
  255. Maternal essential FA patterns during normal pregnancy and their relationship to the neonatal essential FAstatus van Houwelingen M.A. et al (1995) Br J Nutr 74(1): 55-68
  256. Long–chain PUFA, pregnancy and pregnancy outcome van Houwelingen MA et al (2000) Am J Clin Nutr 71:285S-291S
  257. Effect of ALA and LA supplementation during preganncy…. Groot R.HM. et al (2004) Am J Clin Nutr 79(2): 251-260
  258. Essential fatty acids, DHA and human brain Singh M. (2005) Indian J Pediat 72(3):239-242
  259. Visual maturation of term infants fed PUFA-supplemented or control formula for 12 months Birch E.E. et al (2005) Am J Clin Nutr 81(4):871-879
  260. Maternal supplementation with N-3 FA during pregnancy and lactation augments children’s IQ at 4 years of age Helland I.B. etr al (2003) Pediatrics 111(1): e39-44
  261. Increased telomerase activity and vitamin D supplementation in overweight African Americans Int J Obes (Lond). 2011 Oct 11. doi: 10.1038/ijo.2011.197. Georgia Prevention Institute, Department of Pediatrics,  Georgia  Health Sciences University,  Augusta,  GA, USA
  262. The beneficial effect of amalgam replacement on health in patients with autoimmunity, Prochazkova et al, Institute of Dental Research, 1 st Medical Faculty, Charles University, Prague, Czech Republic Neuroendocrinol.Lett. (2004),25: 159 – 166
  263. Toxicology Letters (1999); Supp 1/109: 53 (19 pacientes con SUA)
  264. Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes Toxicol Sci. 2010 Aug;116(2):693. Beedanagari SR, Bebenek I, Bui P, Hankinson O.
  265. Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity. Casper RF, Quesne M, Rogers IM, Shirota T, Jolivet A, Milgrom E, Savouret JF. Mol Pharmacol. 1999 Oct;56(4):784-90.
  266. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Ciolino HP, Yeh GC.
  267. Mol Pharmacol. 1999 Oct;56(4):760-7.
  268. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Chow HH, Garland LL, Hsu CH, Vining DR, Chew WM, Miller JA, Perloff M, Crowell JA, Alberts DS. Cancer Prev Res (Phila). 2010 Sep;3(9):1168-75. doi: 10.1158/1940-6207.CAPR-09-0155. Epub 2010 Aug 17.
  269. Glutathione-S-transferase polymorphism, metallothionein expression, and mercury levels among students in Austria. Gundacker C, Komarnicki G, Jagiello P, Gencikova A, Dahmen N, Wittmann KJ, Gencik M. Sci Total Environ. 2007 Oct 15;385(1-3):37-47. Epub 2007 Aug 22
  270. Nutraceutical supplementation: effect of a fermented papaya preparation on redox status and DNA damage in healthy elderly individuals and relationship with GSTM1 genotype: a randomized, placebo-controlled, cross-over study. Marotta F, Weksler M, Naito Y, Yoshida C, Yoshioka M, Marandola P. Ann N Y Acad Sci. 2006 May;1067:400-7.
  271. Glutathione-S-transferase polymorphism, metallothionein expression, and mercury levels among students in Austria. Claudia Gundackera et,al. Science of The Total Environment
  272. Volume 385, Issues 1-3, 15 October 2007, Pages 37-47
  273. Overview of enzymes of drug metabolism. Author:Meyer, U A. Citation:J.Pharmacokinet-Biopharm. 1996 Oct; 24(5):449-59
  274. Schindler K, Department of Medicine, Division of endocrinology and Metabolism,
  275. Medical University of Vienna (21-10-2006
  276. Valerio et.al, Toxicl Lett. 2001 Feb 3; 119 (1): 49-57
  277. MT Smith., Proc.Natl.Acad.Sci. USA Vol 96,pp 7624-7626, Jul 1999
  278. Rose P. et.al, carcinogenesis 2000 Nov;21 (11):198
  279. Wang et.al., J.Med Food. 2005 Summer; 8(2):198-203
  280. Sulforaphane inhibits extracellular, intracellular,and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc. Natl. Acad. Sci. USA, Vol. 99, Issue 11, pp.7610-7615, May 28, 2002
  281. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane.Proc. Natl. Acad. Sci. USA, Vol. 98, Issue 26, pp.15221-15226, December 18, 2001
  282. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factordeficient mice. Proc Natl Acad Sci USA, Vol. 98, Issue 6, 3410-3415, March 13, 2001 Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc Natl Acad Sci USA, Vol. 98, Issue 6, 3404-3409, March 13, 2001
  283. The War Against Cancer: New Hope, Proceedings of the American Philosophical Society,March 1999, Vol. 143(1), pp. 52-72., Talalay, Paul.
  284. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes.
  285. Food Chem Toxicol 1999 Sep-Oct;37(9-10):973-9
  286. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 10367-10372, September 16, 1997
  287. Electrophile and Antioxidant Regulation of Enzymes that Detoxify Carcinogens. Proc Natl Acad Sci USA 1995 Sep 12;92(19):8965-9
  288. Anticarcinogenic Activities of Sulforaphane and Structurally Related Synthetic Norbornyl Isothiocyanates. Proc Natl Acad Sci USA 1994 Apr 12;91(8):3147-50
  289. Chemical and Molecular Regulation of Enzymes that Detoxify Carcinogens. Proc Natl Acad Sci USA 1993 Apr 1;90(7):2965-9
  290. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc Natl Acad Sci USA 1992 Mar 15;89(6):2399-403
  291. Rapid Detection of Inducers of Enzymes that ProtectAgainst Carcinogens. Proc Natl Acad Sci USA 1992 Mar 15;89(6):2394-8
  292. Chemoprotection against cancer by phase 2 enzyme induction. Toxicol Lett 1995 Dec;82-83:173-9
  293. Subbiah RMT. Nutrigenetics and Nutraceaticals: the next wave riding on personalised
  294. Translational Research 2007 Feb;149:(56-61
  295. Iqbal M. et.al, Pharmacol Toxicol 2003 Jan; 92 (1):33-8
  296. Gow PJ. Et al J. Gastroenterol Hepatol (2004) 19: 154 – 159
  297. Larson AM. Et al (2005) Hepatology 42: 1364 – 137
  298. Lubel JS. Et al (2007) MJA 186(7): 371-372
  299. A.Lozano Teruel “Longevity” (2003)
  300. Estallido Respiratorio y muerte intracelular http//pathmicro.med.sc.edu/ghaffar/innate.htm
  301. Oxidative stress: a theoretical model or a biological reality? Olivier Sorg. Clinique de dermatologie, hôpitaux universitaires de Genève, 24, rue Micheli-du-Crest, 1211 Genève 14, Switzerland Received 9 Match 2004; accepted after revision 27 May 2004 Available online 2 July 2004 Presented by Stuart Edelstein
  302. Regulating redox balance gene expression in healthy individuals by nutraceuticals: a pilot study. Marotta F, Koike K, Lorenzetti A, Jain S, Signorelli P, Metugriachuk Y, Mantello P, Locorotondo N. Rejuvenation Res. 2010 Apr-Jun;13(2-3):175-8. doi: 10.1089/rej.2009.0950.
  303. Ferric Nitrilotriacetate Induced DNA and Protein Damage : Inhibitory Effect of a Fermented
  304. Papaya Preparation. G.Rimbach, Qiong Guo, Takashi Akiyama, Seiichi Matsugo, Hadi Moini, Fabio Virgili and Lester Packer. Anticancer Research 2000 20 : 2907-2914 () Réf: Medline 11062700
  305. Ethanol-Related Gastric Mucosal Damage: Evidence ofa Free Radical-Mediated Mechanism
  306. and Beneficial Effect of Oral Supplementation with Fermented Papaya Preparation,
  307. a Novel Natural Antioxidant. F. Marotta, H. Tajiri, P. Safran, E. Fesce, G. Ideo
  308. Digestion 1999 ; 60 : 538-543 Réf: Medline 10545723
  309. Cyanocobalamin Absorption Abnormality in Alcoholics is Improved by Oral Supplementation
  310. with a Fermented Papaya-derived Antioxidant.F. Marotta, H. Tajiri, R. Barreto, P. Brasca, GM Ideo, L Mondazzi, P. Safran, J Bobadilla, G. Ideo. Hepato-Gastroenterology 2000; 47 :pp 1189-1194 Réf: Medline 11020912
  311. Improvement of Hemorheological Abnormalities in Alcoholics by an Oral Antioxidant. F. Marotta, P. Safran, H. Tajiri, G. Princess, H. Anzulovic , GM Ideo, A Rouge, MG Seal, G. Ideo
  312. Hepato-Gastroenterology 2001; 48 : pp 511-517 Réf: Medline 11379344
  313. Age related Increases in Superoxide Dismutase Activityand related Increases in Superoxide Dismutase Activity and  related Increases in Superoxide Dismutase Activity and  related Increases in Superoxide Dismutase Activity and Thiobarbituric Thiobarbituric Thiobarbituric Acid reactive  reactive Substances : Effect of Fermented Papaya PreparationFPP in Aged Rat Brain  : Effect of Fermented Papaya Preparation FPP in Aged Rat Brain  : Effect of Fermented Papaya Preparation FPP in Aged Rat Brain  : Effect of Fermented Papaya Preparation FPP in Aged Rat Brain. Santiago, L.A., Osato, J.A., Liu, J., Neurochemical Neurochemical Research Research,  Volume 18 Number 6, 1993 1993 1993; pp. 711-717 Réf: Medline 8389992
  314. Radioprotective Radioprotective and Antioxidant Effect of Zinc and Antioxidant Effect of Zinc  and Antioxidant Effect of Zinc Aspartate Aspartate Aspartate et Fermented Papaya Preparation (FPP)  et Fermented Papaya Preparation (FPP). in  in in  in Children with Acute  Children with Acute  Children with Acute Myelo Myelo Myelo and  and  and Lympholeukemias Lympholeukemias. Korkina, E., Osato, J.A., Chivilyeva, I., Samochatova, E., Afanas’ev, I. Supplement to Nutrition Supplement to Nutrition, Volume 11 Number 5, 1995 1995 Réf: Medline 8748221
  315. Free radical scavenging activity of fermented papaya preparation and its effect on lipid peroxide Free radical scavenging activity of fermented papaya preparation and its effect on lipid peroxide  Free radical scavenging activity of fermented papaya preparation and its effect on lipid peroxide  Free radical scavenging activity of fermented papaya preparation and its effect on lipid peroxide level  level and superoxide dismutase activity in iron and superoxide dismutase activity in iron and superoxide dismutase activity in iron- — -induced epileptic foci of rats. induced epileptic foci of rats. Imao K, Wang H, Komatsu M, Hiramatsu M. SAIDO Co., Fukuoka, Japan. Biochem Biochem Mol  Mol  Mol Biol Biol Biol Int Int Int. 1998 1998 1998 Jun;45(1):11-23 Réf: Medline 9635126
  316. FPP ( Fermented Papaya Preparation) , A Novel Natural Antioxidant, prevents FPP ( Fermented Papaya Preparation) , A Novel Natural Antioxidant, prevents FPP ( Fermented Papaya Preparation) , A Novel Natural Antioxidant, prevents FPP ( Fermented Papaya Preparation) , A Novel Natural Antioxidant, prevents. Abstinence Induced Induced  Induced Lipoperoxidation Lipoperoxidation Lipoperoxidation in Moderate Drinkers in Moderate Drinkers. F. Marotta, Reizakovich I., P. Safra, Barbi, G. , G. , G. ISSN : 0172-6390 Hepato Hepato- — -Gastroenterology Gastroenterology Gastroenterology 44 : 1360-1366, 1997 1997 Réf: Medline 9356856
  317. Michael Van Wassenhoven. Scientific framework of Homeopahy. Evidence Based Homeopathy 2012. LIGA MEDICORUM HOMEOPATICA INTERNACIONALIS
  318. Sackett et al BMJ 1996; 312: 71-2
  319. Principios básicos de investigación clínica. JR Laportehttp://www.icf.uab.es/llibre/pdf/Pbic.pdf
  320. The war against polypharmacy: a new cost-effective geriatric-palliative approach for improving drug therapy in disabled elderly people. Isr Med Assoc J. 2007 Jun;9(6):430-4. Garfinkel D1, Zur-Gil S, Ben-Israel J.
  321. Mild hypertension in people at low risk. BMJ 2014; 349 doi: http://dx.doi.org/10.1136/bmj.g5432 (Published 14 September 2014). Stephen A Martin, assistant professor1, Marcy Boucher, assistant professor1, James M Wright, co-managing director2, Vikas Saini, president 3
  322. Reducing Inappropriate Polypharmacy. The Process of Deprescribing. JAMA Intern Med. 2015;175(5):827-834. doi:10.1001/jamainternmed.2015.0324.
  323. The Medication Appropriateness Index (MAI). Polypharmacy and medicines optimisation Making it safe and sound 2013
  324. What are priorities for deprescribing for elderly patients? Capturing the voice of practitioners: a modified delphi process. PLoS One. 2015 Apr 7;10(4):e0122246. doi: 10.1371/journal.pone.0122246. eCollection 2015. Farrell B1, Tsang C2, Raman-Wilms L3, Irving H4, Conklin J5, Pottie K6.
  325. IBP: seguros y eficaces, pero ojo con el uso prolongado y sus efectos. Correofarmaceutico.com Isabel T. Huget itabernero@unidadeditorial.es |  18/10/2010
  326. Maulaz AB, Bezerra DC, Michel P, Bogousslavsky J. Effect of discountinuing aspirin therapy on the risk of brain ischemic stroke. Arch Neurol 2005; 62: 1217–1220.
  327. Discontinuation of nonsteroidal anti-inflammatory drug therapy and risk of acute myocardial infarction. Arch Intern Med. 2004 Dec 13-27;164(22):2472-6. Fischer LM1, Schlienger RG, Matter CM, Jick H, Meier CR.
  328. Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome. JAMA. 2008 Feb 6;299(5):532-9. doi: 10.1001/jama.299.5.532. Ho PM1, Peterson ED, Wang L, Magid DJ, Fihn SD, Larsen GC, Jesse RA, Rumsfeld JS.
  329. Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial. JAMA Intern Med. 2015 May;175(5):691-700. doi: 10.1001/jamainternmed.2015.0289. Kutner JS1, Blatchford PJ2, Taylor DH Jr3, Ritchie CS4, Bull JH5, Fairclough DL2, Hanson LC6, LeBlanc TW7, Samsa GP8, Wolf S8, Aziz NM9, Currow DC10,Ferrell B11, Wagner-Johnston N12, Zafar SY7, Cleary JF13, Dev S14, Goode PS15, Kamal AH7, Kassner C16, Kvale EA15, McCallum JG17, Ogunseitan AB18,Pantilat SZ19, Portenoy RK20, Prince-Paul M21, Sloan JA22, Swetz KM23, Von Gunten CF24, Abernethy AP7.
  330. Withdrawal of statins and risk of subarachnoid hemorrhage. Stroke. 2009 Aug;40(8):2887-92. doi: 10.1161/STROKEAHA.109.552760. Epub 2009 Jun 11. Risselada R1, Straatman H, van Kooten F, Dippel DW, van der Lugt A, Niessen WJ, Firouzian A, Herings RM, Sturkenboom MC.
  331. Title:Overview of enzymes of drug metabolism. Author:Meyer, U A.  itation:J.Pharmacokinet-Biopharm. 1996 Oct; 24(5): 449-59
  332. Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes. Toxicol Sci. 2009 Jul;110(1):61-7. doi: 10.1093/toxsci/kfp079. Epub 2009 Apr 17. Beedanagari SR1, Bebenek I, Bui P, Hankinson O.
  333. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Ciolino HP1, Yeh GC. Mol Pharmacol. 1999 Oct;56(4):760-7.
  334. Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity. Mol Pharmacol. 1999 Oct;56(4):784-90. Casper RF1, Quesne M, Rogers IM, Shirota T, Jolivet A, Milgrom E, Savouret JF.
  335. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res (Phila). 2010 Sep;3(9):1168-75. doi: 10.1158/1940-6207.CAPR-09-0155. Epub 2010 Aug 17. Chow HH1, Garland LL, Hsu CH, Vining DR, Chew WM, Miller JA, Perloff M, Crowell JA, Alberts DS.
  336. Grape antioxidant dietary fiber inhibits intestinal polyposis in ApcMin/+ mice: relation to cell cycle and immune response. Carcinogenesis. 2013 Aug;34(8):1881-8. doi: 10.1093/carcin/bgt140. Epub 2013 Apr 24. Sánchez-Tena S1, Lizárraga D, Miranda A, Vinardell MP, García-García F, Dopazo J, Torres JL, Saura-Calixto F, Capellà G, Cascante M.
  337. La toxicidad del Paracetamol, es la causa más común de fallo hepático agudo en Australia. Gow PJ. Et al J. Gastroenterol Hepatol (2004) 19: 154 – 159
  338. Un trabajo en USA reporta que el 48% de los casos de intoxicación aguda por P, fueron no intencionados. Larson AM. Et al (2005) Hepatology 42: 1364 – 1372
  339. Hepatotoxicidad del paracetamol. Lubel JS. Et al (2007) MJA 186(7): 371-372
  340. Nutraceutical supplementation: effect of a fermented papaya preparation on redox status and DNA damage in healthy elderly individuals and relationship with GSTM1 genotype: a randomized, placebo-controlled, cross-over study. Ann N Y Acad Sci. 2006 May;1067:400-7. Marotta F1, Weksler M, Naito Y, Yoshida C, Yoshioka M, Marandola P.
  341. Methionine dependency and cancer treatment. Cancer Treat Rev. 2003 Dec;29(6):489-99. Cellarier E1, Durando X, Vasson MP, Farges MC, Demiden A, Maurizis JC, Madelmont JC, Chollet P.
  342. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cancer Treat Rev. 2012 Oct;38(6):726-36. doi: 10.1016/j.ctrv.2012.01.004. Epub 2012 Feb 17. Cavuoto P1, Fenech MF.
  343. Los extractos de berro (watercress) son unos potentes inductores QR. Rose P. et.al, carcinogenesis 2000 Nov;21 (11):1983
  344. Cancer Epi Biomarkers: prev 2009 Nov 18 (11): 3118-3125. CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial* Sabrina Peterson,1 Yvonne Schwarz,2 Shuying S. Li,2 Lin Li,2 Irena B. King,2 Chu Chen,2 David L. Eaton,3. John D. Potter,2 and Johanna W. Lampe2)
  345. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
  346. Natl. Acad. Sci. USA, Vol. 99, Issue 11, pp. 7610-7615, May 28, 2002
  347. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane.
  348. Natl. Acad. Sci. USA, Vol. 98, Issue 26, pp. 15221-15226, December 18, 2001
  349. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
  350. Proc Natl Acad Sci USA, Vol. 98, Issue 6, 3410-3415, March 13, 2001
  351. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
  352. Proc Natl Acad Sci USA, Vol. 98, Issue 6, 3404-3409, March 13, 2001
  353. The War Against Cancer: New Hope,
  354. Proceedings of the American Philosophical Society, March 1999, Vol. 143(1), pp. 52-72., Talalay, Paul.
  355. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes.
  356. Food Chem Toxicol 1999 Sep-Oct;37(9-10):973-9
  357. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
  358. Natl. Acad. Sci. USA, Vol. 94, pp. 10367-10372, September 16, 1997
  359. Electrophile and Antioxidant Regulation of Enzymes that Detoxify Carcinogens
  360. Proc Natl Acad Sci USA 1995 Sep 12;92(19):8965-9
  361. Anticarcinogenic Activities of Sulforaphane and Structurally Related Synthetic Norbornyl Isothiocyanates
  362. Proc Natl Acad Sci USA 1994 Apr 12;91(8):3147-50
  363. Chemical and Molecular Regulation of Enzymes that Detoxify Carcinogens
  364. Proc Natl Acad Sci USA 1993 Apr 1;90(7):2965-9
  365. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure
  366. Proc Natl Acad Sci USA 1992 Mar 15;89(6):2399-403
  367. Rapid Detection of Inducers of Enzymes that Protect Against Carcinogens
  368. Proc Natl Acad Sci USA 1992 Mar 15;89(6):2394-8
  369. Chemoprotection against cancer by phase 2 enzyme induction.
  370. Toxicol Lett 1995 Dec;82-83:173-9
  371. La curcuma en la alimentación de los ratones también favorece el aumento de la actividad de las enzimas de la metabolización de la Fase II como la GST y la QR. Iqbal M. et.al, Pharmacol Toxicol 2003 Jan; 92 (1): 33-8
  372. Un incremento en la exposición UVA y una disminución en los niveles cutaneos de Vitamina D(3) puede ser el responsable del incremento de la incidencie de melanoma. Med Hypotheses. 2009 Apr;72(4):434-43. Epub 2009 Jan 19.
  373. Manipulating tumor acidification as a cancer treatment strategy. Altern Med Rev. 2010 Sep;15(3):264-72. McCarty MF1, Whitaker J.
  374. Resveratrol induces apoptosis in pancreatic cancer cells. Chin Med J (Engl). 2011 Jun;124(11):1695-9. Zhou JH1, Cheng HY, Yu ZQ, He DW, Pan Z, Yang DT.
  375. Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. Cancer Lett. 2013 Aug 19;336(2):325-37. doi: 10.1016/j.canlet.2013.03.023. Epub 2013 Mar 27. Tang Q1, Li G, Wei X, Zhang J, Chiu JF, Hasenmayer D, Zhang D, Zhang H.
  376. Resveratrol-induced apoptosis is enhanced in low pH environments associated with cancer. J Cell Physiol. 2012 Apr;227(4):1493-500. doi: 10.1002/jcp.22865. Shamim U1, Hanif S, Albanyan A, Beck FW, Bao B, Wang Z, Banerjee S, Sarkar FH, Mohammad RM, Hadi SM, Azmi AS.
  377. . Gordon CM, Williams AL, Feldman HA, May J, Sinclair L, Vasquez A, Cox JE. Treatment of Hypovitaminosis D in Infants and Toddlers. Journal of Clinical Endocrinology & Metabolism. 2008 Apr 15.
  378. Vasquez A. Interventions Need to be Consistent With Osteopathic Philosophy. [Letter]  JAOA: Journal of the American Osteopathic Association  2006; Sep;106(9):528-9
  379. Vasquez A. Web-like Interconnections of Physiological Factors. Integrative Medicine: A Clinician’s Journal 2006, April/May, 32-37
  380. Vasquez A, Muanza DN. Accolades and Addenda for “Use of Botanicals in Osteoarthritis and Rheumatoid Arthritis”: Comment on Article by Ahmed et al. Evidence-based Complementary and Alternative Medicine. 2005 published on-line December 15
  381. Vasquez A. Subphysiologic Doses of Vitamin D are Subtherapeutic: Comment on the Study by The Record Trial Group. The Lancet .com 2005 Published on-line May 6
  382. Vasquez A, Cannell J. Calcium and vitamin D in preventing fractures: data are not sufficient to show inefficacy. [letter] BMJ: British Medical Journal 2005;331:108-9
  383. Vasquez A. Comment: evaluation of presence of aspirin-related warnings with willow bark. Annals of Pharmacotherapy. 2005 Oct;39:1763.
  384. Vasquez A. Healthcare for our bones: A practical nutritional approach to preventing osteoporosis. [Letter]. Journal of Manipulative and Physiological Therapeutics 2005; 28: 213
  385. Muanza DN, Vasquez A, Cannell J, Grant WB. Isoflavones and Postmenopausal Women. [letter] JAMA: Journal of the American Medical Association 2004; 292: 2337
  386. Vasquez A, Manso G, Cannell J. The Clinical Importance of Vitamin D (Cholecalciferol): A Paradigm Shift with Implications for All Healthcare Providers. Alternative Therapies in Health and Medicine 2004; 10: 28-37.
  387. Vasquez A. Musculoskeletal disorders and iron overload disease: comment on the American College of Rheumatology guidelines for the initial evaluation of the adult patient with acute musculoskeletal symptoms. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology 1996; 39:1767-8
  388. Integrative Orthopedics (‘04,’07,’12)
  389. Integrative Rheumatology (‘06,’07,) revision and expansion: Integrative Rheumatology, Nutritional Immunology, Functional Inflammology (Third Edition, ‘13pending)
  390. Musculoskeletal Pain: Expanded Clinical Strategies (’08, published by IFM)
  391. Chiropractic and Naturopathic Mastery of Common Clinical Disorders (‘09)
  392. Integrative Medicine and Functional Medicine for Chronic Hypertension (‘10)
  393. Chiropractic Management of High Blood Pressure & Chronic Hypertension (‘10), Integrative Chiropractic Management of High Blood Pressure & Chronic Hypertension  (‘11)
  394. Migraine Headaches, Hypothyroidism, and Fibromyalgia (‘12)
  395. Fibromyalgia in a Nutshell (‘12)
  396. Foundational Assessments and Wellness Promotion in Integrative Chiropractic and Functional Medicine (‘12)
  397. Functional Immunology and Nutritional Immunomodulation: Presentation Slides Part 1: Introduction to the Use of Nutrition and Functional Medicine in the Prevention and Treatment of Chronic Inflammation, Allergy, Autoimmunity, and the New FIND SEX Acronym (‘12),
  398. International Journal of Human Nutrition and Functional Medicine (‘13) Int J Hum Nutr Funct Med. Org
  399. Dr Vasquez’s Presentation on Migraine Headaches, Fibromyalgia, and Chronic Fatigue Syndrome (‘13)
  400. Functional Inflammology, Allergy, Asthma, and Dysbiosis (‘13)
  401. Selected Topics in NeuroMusculoSkeletal Medicine (‘13)
  402. The tragic irony is that the vast majority of medical doctors—and therefore the largest component of the healthcare delivery system in the world—are untrained in nutrition and therefore incapable/ incompetent to deliver nutrition assessment and treatment to their patients. J Clin Gastroenterol. 2009 Jul;  Vetter. J Am Coll Nutr 2008 Apr
  403. Thus, not surprisingly, medical doctors practice in a way that focuses on 1) the diagnosis, and 2) the drug(s) for the diagnosis. Ely. BMJ 1999 Aug
  404. The medical profession generally lacks appreciation of how body systems work interactively and interdependently. Vasquez. Integrative Med. 2006 Apr
  405. Functional Medicine Matrix illustrated by Alex Vasquez (2003): The “Matrix” provides a illustration of the interdependency of physiologic factors and organ systems;  this version was published as Vasquez, Integrative Medicine, 2006
  406. Scott MP et al, “Grain composition and amino acid content in Maite cultivars representing 80 years of comercial Maite varieties “   Maydica, 2006; 51; 417.
  407. Seneweera SP, Conroy JP et al “ Growth ,grain yield and quality of rice (Oriza sativa L )  in response to elevevated CO2 and Phosphorus nutrition “  Soil Sci Plant Nutr, 1997, 43)
  408. Carbonaro M Mattera M et al “ Modulation of antioxidant compounds in organic vs concentional fruits ( peach, pruna persica L,  and pear ,pyrus communis L)   “ J  Agric Food Chem, 11 septiembre 2002; 50(19)
  409. (Lee JH, Talcott ST et al “ Fruit maturity and juice extraction influences ellacic acid derivatives and other antioxidant polyphenolics in muscadine grapes “ J Agric Food Chem, 2004; 28 enero , 52(2))
  410. Clin Toxicol, 2008, diciembre, 46(10)
  411. Bronstein AC, Spyker DA et al “ 2008 Annual Report of the American Association of Poison Control Center´s Nacional Poison Data System ( NPDS); 26 th Annual Report”  Clinical Toxicology, 2009, 47; 911)
  412. Henry Ginsberg de la Universidad de Columbia; Annual Meeting of  American College of Cardiology , 2010; New Englan Journal of Medicine, 2010
  413. Larry L Hilblom Islet Research Center at UCLA, Diabetes, Mayo 2009
  414. Literature on Vitamin D and health Hill be available” Wildrose Ballroom at the Sheraton Suites Hotel.Glagari, 13 Octubre 2005
  415. Fisher L, Fisher AA et al “ Prevalence of vitamin K and vitamin D deficiency in patients with hepatobiliary and pancreatic disorders” Nutr Res, 2009, 29(9)
  416. Palan PR , Mikhail MS et al “ Effects of oral, vaginal, and transdermal hormonal contraception on serum levels of coenzyme (Q(10) , vitamin E and total antioxidant activity” Obstet Gynecol Int, 2010, 10 de agosto)
  417. Fatouh AAA, Abd-Al-Aziz AM et al Magnesium level in chronic asthmatic children-effect of corticosteroid treatment “ Internacional Journal of Food Safety; Nutrition and Public Health, 2009, 2(2)
  418. Julio del 2005 en el International Journal of Clinical Pharmacology and Therapeutics. La toma de probióticos, vitaminas y minerales en los últimos 3 meses, reduce la incidencia de infecciones del tracto respiratorio, realizado por el Dr. Schrezenmeir
  419. Winkler P, de Vrese M, Laue CH ,Schrezenmeir et al “ Effect of dietary supplement conatining probiotic bacteria plus vitamins and mineral son common cold infections and cellular immune parameters” Int J Clin Pharmacl Ther; 2005; 43(7).
  420. Kidd PM “ neurodegeneration from mitochondrial insufficiency:nutrients ,stm cells, growth factors,and prospects for brain rebuilding using integrative management “ Altern Med Rev, 2005
  421. Jeffrey S, Nutrigenomics of the Metabolic Syndrome, 2005
  422. Moore JB, Blanchard RK, Cousins RJ, “ Dietary zinc modulates gene expression in murine thymus : results from a comprehensive differential display screening,” 2003, 100(7)
  423. Jasper Rine et al, Universidad de California,  Proceedings of the National Academy of Sciences, 3 de junio 2008)
  424. Maggini S , Horning DH et al, “ Immune enhancinh role of vitamin C and zinc and effect on clinical conditions” Ann Nutr Metab 2006, 50(2)
  425. Leila Ammar-Keskes, et al “ Sperm oxidative stress and the effect o fan oral vitamin E and selenium supplement on semen quality in infertile men “  Arch Androl, 2003; 49.
  426. Dr Douglas Seidner, Clinical Gastroenteology and hepatology, Abril 2005),
  427. Premkuma VG, Yuvaraj S et al, «  Effect of coenzyme Q 10, riboflavine and niacine on serum CEA and CA 15-3  levels in breast cancer patients undergoing tamoxifen therapy «   Biol Pharm Bull, 2007 ; 30(2).
  428. Qiao YL, Dawsey SM et al “ Total and cancer mortality alter supplementation with vitamin and minerals: Follow-up of the Linxian General Population Nutrition Intervention Trial”   J Natl Cancer Ints, 2009, 24 marzo.
  429. Berger MM; Shenkin A “ Update on clinical micronutrient supplementation studis in the critically ill” Current Opinion in Clinical Nutrition and Metabolic care; 2006, 9(6)
  430. Block G, Jensen CD et al “ Usage patterns , health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional study” Nutr, J, 2007; 6(1) ( prof de epidemiologia y  Universidad de California; Berkeley)
  431. Sanjay Sharma, Cost Effective Ocular Health Policy Unit at Queen´s University in Ontario.  Annual American Academy of Ophthalmology.  Octubre 2002
  432. Erie JC, Pulido JS et al “ reduced zinc and copper in the retinal pigment epithelium and choroid in age-related macular degeneration “   Am J Opthalmol, 2009, 147(2)
  433. Jacques PF, Taylor A, Moeller S, et al. « Long term nutrient intake and 5 year change in nuclear lens opacities.” Arch Ophthalmol 2005;  abril, 517-526
  434. Wojtowicz JC, McCulley JP et al “ Pilot ,prospective , randomized double masket, placebo controlled clinical trial of an omega 3 supplement for dry eye”  Cornea, 2010, 28 octubre)
  435. Yilmaz H, Sahin S et al “ Effects of folic acid and N acetyl Cysteine on plasma homocysteine levels and endothelal function in patients with coronary artery disease” Acta Cardiol, 2007; 62(6)
  436. Witte KK, Nikitin NP et al “ The effect of micronutrient supplementation on quality of life and left ventricular function in elderly patients with chronic heart failure “  Eur Heart J, Aug, 4; 2005)
  437. Moertl D, Berger R et al “ Dose-dependent decrease of platelet activation and tissue factor by omega -3 polyunsaturated fatty acids in patients with advanced chronic heart failure” Thromb Haemost, 2011,28 de julio
  438. Yasuhara T, Hara K et al “ Dietary supplementation exerts neuroprotective effects in ischemic stroke model “ Rejuvenation Res, 2008, febrero, 11(1)
  439. Kumar S, Sparks PB et al “ Effects of chronic omega 3 polyunsaturated fatty acid supplementation on human atrial mechanical function after reversion of atrial arrhytmias to sinus rhythm: reversal of tachycardia mediated atrial cardiomyopathy  with fish oils “  Heart Rhythm , 2011, 10 de enero.
  440. Gao L, Mao Q et al “ Effects of coenzyme Q 10 on vascular endotelial function in humans: A meta-analysis of randomized controlled trials” Atherosclerosis, 2011, 25 octubre)
  441. Zou K, Liu G et al “ Selenium for preventing Kashin-Beck osteoarthropaty in children: a metaánalysis”  Osteoarthritis Cartilage, 2008; agosto 5)
  442. Long et al ” The comparative impact of iron, the B-complex vitamins, vitamins C and E, and selenium  on diarrheal pathogen outcomes relative to the impact produced by vitamin A and Zinc ” Nutrition Reviews; 2007; 65(5)
  443. Abdulhamid I, Beck FW, et al “  Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis “  Pediatr Pulmonol , 2008; 43(3)
  444. Ken Brown, International Zinc Nutrition Consultative Group  (IZINCG) The United Nations University and Internacional Union of Nutrition Sciences “ Assesment of the risk of zinc deficiency in populations and options for this control “. UN Standing Commitee on Nutrition, 23 de Marzo 2004,
  445. Kalliomaki M,  Salminen S  et al “ Probiotics during the first 7 years  of life : a cumulative risk reduction  of eczema  in a randomized placebo controled  trial “  J Allergy Clin Immunol , 2007, 119)
  446. Gruber C, Wahn U et al “ reduced occurrence of early atopic dermatitis because of immunoeactive prebiotics among low atopy risk infants “  J Allergy Clin  Immunol, 2010, 9 septiembre.
  447. Gariballa S, Foster S et al “ Dietary supplementation and quality of life of older patients: a randomized , double blind, placebo-controlled trial “ J Am Geriatr Soc, 2007, 18 Oct.)
  448. Caribella S, Foster S et al “ Effects of dietary supplements on depressive syntoms in older patients . A randomized double  blind placebo controlled trial “  Clin Nutr 2007, julio 25
  449. Remington R, Chan A et al “ Efficacy of a vitamin/Nutraceuticals formulation  for moderate stage to later stage Alzheimer´s disease: a placebo controlled pilot study.” Am J Alzheimer´s Dis Other Demen.  2008, Dec 3
  450. Huskisson E, Morggani S et al “ The influence of micronutrients on cognitive function and performance “ Journal of Int Medical Research, 2007; 35(1)
  451. Magis D, Ambrosini A et al “ A randomized double blind, placebo controlled trial of thioctic acid in migraine prophylaxis “  Headache, 2007, enero; 47(1)
  452. Parachikova A, Green KN et al “ Formulation of a medical food cocktel for Alzheimer´s disease: beneficial  effects  on cognition and neuropathology in a mouse model  of the disease”  PLoS One, 2010, 17 de noviembre; 5(11)
  453. Bousquet M et al “ Impact of omega 3 fatty acids in Parkinson´s disease” Ageing Res Rev, 2011, 23 marzo
  454. Iso Hiroyasu et al, Intake of Fish and omega 3 fatty acids and the risk of stroke en women “ JAMA; 2001; 285)
  455. He K et al “ Fish comsumption and risk of stroke in men “  JAMA; 2002,  288
  456. Leila Ammar-Keskes, et al “ Sperm oxidative stress and the effect o fan oral vitamin E and selenium supplement on semen quality in infertile men “  Arch Androl, 2003; 49.
  457. Sheweita SA, Tilmisany AM, et al “  Mechanism of male infertility. Role of antioxidants”  Curr Drug Metab, 2005, 6(5)
  458. Agarwal A, Sekhon LH et al “ The role of antioxidant therapy in the treatment of male infertility “  Hum Fértil ( Camb), 2010, diciembr; 13(4)
  459. Ross C, Morriss A et al “ a Systematic review of the effects pf oral antioxidants on male infertility “ Reprod Biomed Online, 10 marzo, 2010)
  460. Thomas SL, Hakk Aj et al “ Micronutrient intake and the risk of herpes zoster: a case control study” Int J Epidemiol, 2005
  461. Wolvers DA , van Herpen-Brokmans WM et al, “  Effect of a mixture of micronutrients ,but not of bovine colostrum concentrate, on immune function parameters in healthy volunteers:a randomized placebo-controlled study”  Nutr J, 2006;21(5)
  462. Eintergerst ES, Maggini S et al “ Immune enhancing role of cvitamin C and zinc and effect on clinical conditions “  Ann Nutr Metab, 2006, 50(2)
  463. Salemi G, Gueli MC et al “ Blood lipids, homocysteine, stress factors, and vitamins in clinically stable multiple sclerosis patients”   Lipids Health Dis, 2010, febrero 18;
  464. Gori A, Rizzardini G et al “ Specific prebiotics modulate gut microbiota and immune activation in HAART naive HIV infected adults “ Mucosal Immunol, 2011, septiembre)
  465. Furrie E , Mac Farlane, et al “ Synbiotic therapy (bifidobacterium  longum /synergy 1) initiates resolution  of inflammation  in patients with active  ulcerative colitis : a randomized controlled  pilot trial “ Gut, 2005,  54)
  466. Lindsay JO Whelan K et al “ Clinical microbiological, and immunological  effects of fructooligosacchaide in patients with Crohn´s  disease” Gut, 2006, 55)
  467. Velicer CM, Urlich CM et al “ Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review “  J Clin Oncol, 2008, 26(4)
  468. Conklin KA “ Coenzyme Q 10 for prevention of anthracycline induced cardiotoxicity.” Integ Cancer Ther, 2005, jun 4(2)
  469. Hardman WE. “ Omega 3 fatty acids to augment cancer therapy “ J Nutr, 2002, nov 132(11 supp)
  470. Mayland CR , bennet MI et al “ Vitamin C deficiency in cancer patients “  Paliat Med, 2005, enero 19( 1)
  471. Hu J, Mery L et al ” Diet and vitamin or mineral supplementation and risk of rectal cancer in Canada ”  Acta Oncol, 2007, 46(3)
  472. Al- Tonbary Y, Fouda A et al Hematology/Oncology Unit, Mansoura University Children´s Hospital. “  Vitamin E and N-acetylcysteine as antioxidant adjuvant therapy in children with acute lymphoblastic leukemia “  2009; 20 octubre;
  473. Sivrioglu EY, Kirli S et al “ The impacto f omega 3 fatty acids, vitamins E and C supplementation on treatment outcome and side effects in schisophrenia patients treated with haloperidol : an open label pilot study “  Prog Neuropsychopharmacol BIol Psychiatry, 2007; 13 de julio, )
  474. Hedelin M, Weiderpass E et al “ Dietary intake of fish,omega 3, omega 6 polyunsaturated fatty acids and vitamina D and the prevalence of psychotic like symptoms in a cohort of 33.000 women from the general population “ BMC Psychiatry, 2010, 10(1)
  475. Gopinath B, Flood VM,,Paul Mitchell, Universidad de Sidney; “ Comsumption of omega 3 fattu¡y acids and fish and risk of age related hearing loss “  American Journal of Clinical Nutrition, 9 de junio 2010)
  476. Robinowitz PM, Pierce Wise J, et al “ Antioxidant status and hearing function in noise exponed workers “ Hear Res, 2002, nov 172(1-2)
  477. Joachims HZ, segal J et al “ Antioxidants in treatment of idiopathic sudden hearing loss”  Otol Neurol 2003, jul 24(4)
  478. Seidman M, Babu S et al “ Effects of resveratrol on acoustic trauma “  Otolaryngol Head Neck Surg, 2003, nov 129(5)
  479. Shen W, Liu K, et al “ R –alpha lipoic acid and Acetyl –L-carnitine complementarily promote mitochondrial biogénesis in murine 3T3-L1 adipocites “ Diabetologia, 2008; 51(1)
  480. Lai MH, “ Antioxidant effects and insulin resistance improvement of chromium combined with vitamin C and E supplementation for type 2 diabetes mellitus” J Clin Biochem  Nutr, 2008 nov; 43(3)
  481. Shidfar F, Hagáis M et al “ Effects of combination of zinc and vitamin A supplementation on serum fasting blood sugar, insulin, apoprotein B and apoprotein A-1 in patients with type 1 diabetes”  Int Food Sci Nutr, 2010, 61(2)
  482. Garcia –Medina JJ, Pinazo-Duran MD et al, “ A 5 year follow-up of antioxidant supplementation in type 2 diabetic retinopathy” Eur  J Ophthalmol, 2010, 30 diciember)
  483. Ranganathan N, Ranganathan P et al “ Pilot study of probiotic dietary supplementation for  promoting healthy kidney function in patients with chronic kidney disease”   Adv Ther 2010, 16 de agosto
  484. Madsen T, Schmidt EB et al “ Marine n-3 polyunsaturated fatty acids in patients with end stage renal failure and in subjects without kidney disease: a comparative study”  J Ren Nutr, 2010,  9 de septiembre)
  485. Oya J, Iwamoto Y et al “ Intake of n-3 polyunsaturated fatty acids and non alcoholic fatty liver disease: a cross sectional study in Japanese men and women” Eur J Clin Nutr, 2010, 4 de agosto.
  486. Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET). ( Claes  Held, et al  Circulation, 5 de marzo 2007)
  487. Rowley WR, Bezold C et al “ Creating public awareness:  state 2025 diabetes forecats “ Popul Health Manag, 2012, january, 27,
  488. Gregg EW, et al “ Are children the future of type 2 diabetes prevention? “  N Engl J Med, 11 febrero 2010, 362(6)
  489. Diabetes División, Boureau of cardeio respiratory Diseases and Diabetes, Laboratory Centre for Disease Control , health protection Branco. Diabetes in Canada: Nacional Stadistics and Opportunities form Improved Surveillance , Prevention, and Control. 1999, Health Canada.)
  490. Canadian Diabetes Associarion. About Diabetes:The prevalence and costs of diabetes. Canadian Diabetes association wetsite. Enero, 31, 2004
  491. Gonzalez R, Carmena R et al” Plasma homocysteine levels are associated with ulceration of the foot in the patients with type 2 diabetes mellitas” Diabetes Care  Metab Res Rev, 2010, 26(2)
  492. Diabetes Care, 1997, 20;
  493. Dr Thomas Jeerakathil,Journal of American Heart Associations Stroke Junio 2007
  494. Kristine Yaffe, S Francisco Medical Center ,agosto 2006.
  495. Agosto 2005, Archives of Neurology.
  496. Bethel MA, Sloan FA et al “ Longitudinal incidente and prevalence of adverse outcomes of  diabetes mellitus in elderly patients” Arch Inter. Med, 2007, 167)
  497. Oscar H Franco, University Medical Center Rótterdam,  ( Framingham Heart Study.   Archives of Internal Medicine;  11 de junio 2007)
  498. Anne Cust, Universidad Melbourne, julio 2008
  499. Coughlin et al ,  Am J Epidemiol, 2004; 159
  500. Larsen N, Jakobsen M et al “  Gut microbiota in human adults with type 2 diabetes differs from no diabetic adult”  PLoS One, 2010, 5(2)
  501. An Pan; Michel Lucas; Qi Sun; Rob M. van Dam; Oscar H. Franco; JoAnn E. Manson; Walter C. Willett; Alberto Ascherio; Frank B. Hu. “Bidirectional Association Between Depression and Type 2 Diabetes Mellitus in Women.”  Arch Intern Med, Nov 2010;
  502. Nanri A, Tsugane S et al “ Rice intake and type 2 diabetes in japanese men and women : the Japan Public Health Center Based Prospective Study “ Am J Clin Nutr, 2010, 27 octubre
  503. Ellis EM, “ reactive carbonils and oxidative stress:potencial for therapeutic intervention” Pharmacol Ther, 2007; jul, 115(1)
  504. Pennathur S, Ido Y et al “ Reactive carbonyls and polyunsaturated fatty acids produce a hydroxyl radical-like species: a potenctial pathway for oxidtive damage of retinal proteins in diabetes “ J Biol Chem, 2005, 17 junio, 280(24)
  505. Krishnan S, Coogan PF et al “ Comsumption ofrestaurant foods and incidence of type 2 diabetes  in african-american women”  Am J Clin Nutr, 2010, febrero, 91(2)
  506. Scheen AJ et al “ From obesity to diabetes ; Why, When and Who? “ Acta Clin belg, 2000, enero, 55(1)
  507. Bradford Lowell de Harvard. Publicado en British Journal  Nature, agosto 2007
  508. Journal of the American Medical Association, ( JAMA), 2004, 11 febrero.
  509. Akbaraly TN, Arnaud J et al “ Plasma selenium and risk od dysglicemia in an elderly French population: results from the prospective Epidemiology of Vascular Ageing Study”  Nutr Metab, (lond) , 2010, marzo, 7(1)
  510. Forohui NG; Luan J et al “ Baseline serum 25 hydroxivitamin D is predictive  of future glycemic status and insulin resistente the Medical  Research Council  Ely  Prospective Study  19090-2000”  Diabetes, 2008; actubre;  57(10)
  511. Tamariz et al “ Blood viscosity and hematocrit as risk factors for type 2 diabetes mellitus. “ Amrican Journal of Epidemiology, 2008;  168(10)
  512. Knowler WC, Barret Connor E et al “ Reducction in the incidence of type 2 diabetes with lifestyle intervention or mettformin”  N Engl J Med, 2002, 7 febrero; 346(6)
  513. Luoto R, Laitinen K et al “ Impact of maternal probiotic supplemented dietary counseling on pregnancy outcome and prenatal and post natal  growth: a double blind, placebo controlled study”  J Nutr, 2010, 4 febrero;1:8
  514. Patrice Carter, University of Leicester, England; British Medical Journal, , 2010, 19 de agosto
  515. Sun Q, Hu FB et a “ White rice, brown rice, and risk of type 2 diabetes  in US men and women “  Arch INtern Med, 2010, junio, 170(11)
  516. Tao Xia and Wang, Universidad del Este de China y Universidad de Shangai; Journal of the Science of Food and Agriculture; Julio 2007;)
  517. Lai MH, et al “ Antioxidant effects  and insulin resistance improvement of chromium  combined with vitamin  C and E supplementation for type 2 diabetes  mellitas “  J Clin Biochem Nutr, 2008,  noviembre; 43(3)
  518. Kim CW, Joo NS et al “ Effects of short term chromium supplementation on insuin sensitivity and body composition in overweight children: randomized, double blind, placebo controlled study” J Nutr Biochem, 2011, 7 enero
  519. Albarracin CA et al “ Chromium picolinate and biotin combination improves glucosa metabolism in treated, uncontrolled overweight too bese patients with  type 2 diabetes”Diabetes Metab Res Rev, 2008, 24
  520. Andrew P.Levy, et al “ Vitamin E supplementation reduces cardiovascular events in a subgroup of midle –aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype. A prospective doruble-blinded clinical trial “  Arterioscler Thromb Vasc Biol, 2007; nov 21)
  521. Aljabri KS, Khan MJ et al “ Glycemic changes alter vitamin D supplementation in patients with type 1 diabetes mellitus and vitamin D deficiency” Ann Saudi Med, 2010, 30(6)Psaltopouloua T, Panagioyakosb DB  et al “  Dietary antioxidant capacity is inversely associated with diabetes biomarkers . the ATTICA study”  Nutrition, Metabolism, and Cardiovascular Disease. Article in presss. 2010
  522. Diabetes Care, 30; 813; 2007; J Nutr , 136; 2006, )
  523. Mag B, Wolters M et al “ Effects of a cinnamon extract on plasma gluocose, HbA, and  serum lipids in diabetes mellitus  type 2” Eur J Clin Invest, 2006 mayo, 36(5); )
  524. Jain SK, Rains J et al “ Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose treated cultured monocytes and blood levels of FNT-alpha, IL-6, MCP-1 glucose , and glycosylated hemoglobin in diabetic rats” Antioxi Redox Signal, 2008, oct 31
  525. Tsuneki H, Ishzuka M et al “ Effects ogf green tea on  blood glucosa levels and serum proteomic patterns in diabetic ( dd/db) mice and on glucose metabloism in healthy humans “ BMC Pharmacol, 2004; aug 26; 4)
  526. Waltner-Law et al, 2002
  527. Fukino Y, Ikeda A et al . Eur J Clin Nutr . 2007; Jun 6
  528. Sun Q, Hu FB et al “ A prospective study of zinc inatke  and risk of type 2 diabetes in women  “ Diabetes Care, 2009, enero 26.
  529. Ayyalusamy Ramamoorthy , University of Michigan; Journal of the American Chemical Society; julio 2010
  530. Huerta MG, Roemmmich JN et al “ Magnesium deficiency is associated with insulin resistance in obese children” Diabetes Care, 2005; may ,28(5)
  531. Lopez Ridaura R, Willet WC et al “ magnesium intake and risk of  type 2 diabetes in men and  women “ Diabetes Care, 2004, jan 27(1)
  532. Kamenova P et al “ Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha lipoic acid “  Hormones / Athens) , 2006, oct-Dec, 5(4)
  533. Rajasekar P, Anuradha CV et al “ L acrnitine inhibits protein  glicaction in vitro and in vivo :evidence for a role in diabetic managenet” Acta Diabeto, 2007,  junio, 44(2)
  534. Evans JD, Jacobs TF et al “ Role of acetyl carnitine in the treatment of diabetic peripheral neuropathy” Ann Pharmacother , 2008; nov; 42(11)
  535. Jill M Norris, et al Journal of the American Medical Association; 2007, 26 de septiembre
  536. Diabetologia, 2005, Volumen 48, número 8
  537. Guía Europea de Prevención Cardiovascular en la Practica Médica, 2008)
  538. Lindahl et al,; The England Journal of Medicine, 2000;  Parkard et al. The E J M, 2000,
  539. Lindahl et al 2000,Packard et al 2000, Rader et al, 2000
  540. Circulation, 1 Agosto, 2006.
  541. Emory University. Nacional Health and Nutrition Examination Survey ( NHANES III).   Clinical Nutrition, diciembre 2002
  542. Ganotakis ES, Mandalaki K et al “ Subclinical hypothyroidism and lipid abnormalities in older women attending a  vascular disease prevention clilnic : Effect of thyroid  replacement therapy”  Angiology, 203, 54(5)
  543. Annual meeting of the American Thyroid Association, Noviembre 2007)
  544. Virend Somers, Clínica Mayo en Rochester; 2008
  545. Oscar Franco et al; Warwick Medical School , Circulation; 2 de noviembre 2009)
  546. Geetha Raghuveer. American Heart Association´s Scientific Sessions, 2008, New Orleans.
  547. Kirsten Bibins-Domingo de la Universidad de California-San Francisco. New England Journal of Medicine, Diciembre 2007
  548. Martins D, Wolf M, et al “ Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United Stataes:data from the Third Nacional Health  and Nutrition Examination Survery”  Arch Inter. Med, 2007, jun 11; 167(11)
  549. Michael F Holick, O´Keefe, et al  Journal of the American College of Cardiology, 9 Diciembre 2008
  550. Emory University. Nacional Health and Nutrition Examination Survey ( NHANES III).   Clinical Nutrition, diciembre 2002.
  551. Senes M, Erbay AR et al “ Coenzyme Q 10 and high sensitivity  C reactive protein in ischemic and idiopathic dilated cardiomyopathy “ Clin Chem Lab Med, 2008; feb 6)
  552. Journal of the American College of Cardiology,  28 octubre 2008
  553. Sekikawa A, Curb JD et al “ Marine derived n-3 fatty acids and atheroscelrosis in japanese-american, and white men: a cros-sectional study “  J Am Coll Cardiol, 2008, 52.
  554. Arterioscler Thromb Vasc Biol, 2003, 1 julio , 23(7)
  555. JAMA, 7 noviembre 2001, 286(17)
  556. Bao B et al “ Zinc decreases C reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent” Am J Clin Nutr, 2010, 91;
  557. Lindahl et al 2000,Packard et al 2000, Rader et al, 2000)
  558. Ridker et al, New England Journal of Medicine,
  559. N Engl J Med, 2002, 14 nov; 347(20)
  560. JAMA, 12 octubre 2005
  561. Naruszewicz M, Jankowska EA et al “ Hyperhomocysteinemia in patients with symptomatic chronic heart faillure: Prvalence and prognostic importante-pilot study”  Atherosclerosis, 2006,
  562. Riza Erbay A, Turhan H et al “ Elevated level of plasma homocysteine in patients with slow coronary flow” Int J Cardiol, 2005; 102 (3
  563. J Periodontol, 2000, oct 71(10))
  564. Adnan I Quershi, Universidad de Buffalo; Archives on Internal Medicine, 9 julio 2001
  565. Covas MI, Nyyssonen K et al “ The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial “  Ann Inter. Med, 2006, sep 5; 145(5)
  566. Circulation el 17 de febrero 2009
  567. Teresa T, Fung . et al . Archives of Neurology, febrero 2009
  568. British Journal of Nutrition, Mayo 2008
  569. Maiyoh GK, et al “ Cruciferous indole 3 carbinol inhibits aplipoprotein B secretion in HepG2 cells “ Cells J Nutr, 2007, 137.
  570. Keith ME, Walsh NA et al “ B-vitamin deficiency in hospitalizad patients with Herat failure “ J Am Diet Assoc, 2009, 109(8)
  571. Shargorodsky M, Zimlichman R et al “ Effect of long term treatment with antioxidants ( vitamin C, vitamina E, coenzyme Q 10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiavascular factors “  Nutr Metab (Lond) 2010, 7(1)
  572. Pieper JA, et al “ Overview of niacin formulations: differences in pharmacokinetics, efficacy , and safety”  Am J  Health Syst Pharm, Julio 1, 2003, 60(supp 2)
  573. Cardiology, 12 agosto 2008
  574. B. Singh, et al “ Effects of carni Q-gel ( ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon Study “  Acta Cardiol, 2007; 62(4)
  575. Kubota Y, Moriyama Y et al “ serum vitamin C concentration and hs-CRP level in middle aged  Japanese men and women” Atherosclerosis, 2009; 7 agosto.
  576. Nam CM, Oh KW et al “ Vitamin C intake and risk of ischemic heart disease in a population with a high prevalence of smoking “  J Am Coll Nutr, 2003, 22(5)
  577. S Matthijs Boekholdt of Academic Medical Center in Amsterdam and Cambridge University in England. Publicado en British Journal of Nutrition, september, 2006.
  578. Dobnig H, Pilz S et al “ Independent associactiation of low serum 25-ydroxyvitamin D and 1, 25 –hydroxyvitamin D levels with all-cause and  cardiovascular mortality “  Arch Intern Med, 2008; 168(12)
  579. Dobnig H, Pilz S et al “ Independent Association of low serum 25 hydroxyvitamin D and 1, 25 .dihydroxyvitamin D levels with all-cause and cardiovascular mortality “ Arch Intern Med, 2008, 23; 168(12)
  580. Biochemistry and Molecular Biology Internacional, 1998, Vol 46, Iss6,
  581. Wu Y, Li S et al “ Ginkgo Biloba extrac improves coronary blood flor in healthy elderly adults: role of endothelium-dependent vasodilation “  Phyromedicine, 2008; feb 5)
  582. Li HJ, Liu C et al “ Curcumin prevents and reverses murina cardiac hypertrophy “  J Clin Invest, 2008, marzo 3; 118(3)
  583. Wang QM, Wang LS et al “ Association between green tea intake and coronary artery disease in a chinese population “  Circ J, 2009, 17 diciembre.
  584. J Nutr , 2008, septiembre; 138(9)
  585. Jang EM, Choi MS et al “ beneficial effects  of curcumin on hyperlipdemia  and insulin resistance in high fat fed hamsters”  Metabolism, 2008; 57(11)
  586. Futterman et al, 1998)
  587. Lexiton´s Veterans Affairs Medical Center y en la University of Kentucky, que participaron el ( COURAGE trial), fue presentado en el Annual Meeting  de American College of Cardiology en New Orleans, 2007.
  588. Klerk M, Verhoef P et al “ MTHFR 677-T polymorphism and risk of coronary heart disease: a meta analysis “ JAMA , 2002; octiber 23/30; 288(16)
  589. Haim M, Tanne D, et al,  “ Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease . “ Cardiology,2007, (1)
  590. Ariyo AA, Thach C et al. N Engl J Med, November, 27, 2003; 349  El aumento de Lpa se relaciona con aumento de riesgo cardiovascular
  591. Danesh J , Collins R, Peto R et al ” Lipoprotein (a)  and coronary heart disease.
  592. meta-analysis of prospective studies ” Circulation, 2000, 102.)
  593. Muñoz JA, Garcia C et al ” Effect of vitamin C on lipoproteins in healthy adults ” Ann Med Interne, 1994; 145,)
  594. Jenner JL, Jacques PF et al ” Ascorbic acid supplementation does not lower plasma lipoprotein(a) concentrations ”  Atherosclerosis, 2000; 151),
  595. Bostom AG, Hume AL, Eaton CB et al ” The effect of high-dose ascorbate supplementation on plasma lipoprotein(a) levels in patients with premature coronary heart disease”  Pharmacotherapy; 1995; 15.)
  596. Gavish D, Breslow JL et al ” Lipoprotein(a) reduction by N-acetylcysteine ”   Lancet, 1991; 337:,  Kroon AA, Demacker PN et al “
  597. N-Acetylcysteine and serum concentrations of lipoprotein (a) ” J Inter Med, 1991; 230)
  598. Carlson LA, Hmasten A et al ” Pronunced lowering of serum levels of lipoprotein(a) in hyperlipaemic subjects treated with nicotinic acid ”  J Inter Med, 1989; 226
  599. Golberg A, Alagona P jr, et al ” Multiple-eficacy and safety of an extended-release frorm of niacin in the management og hyperlipidemia”  Am J Cardiol, 2000; 85.
  600. Atherosclerosis, Agosto, 2006
  601. Danesh J, “ Antibiotics in the prevention of  heart attacks “   Lancet, january 29, 2005; 365
  602. Pussinen et al “ Periodontitis decreasses the antiatherogenic potency of high density lipoprotein “  Journal of Lipid  Research, 2004; 45.
  603. Kop WJ, Gottdiener JS, “ The Role of Immune System Parameters in the Relationship Between Depression and Coronary Artery Disease “ Psychosomatic Med, 2005; 67.
  604. Graham DJ, Campen D et al “ Risk of acute myocardial infarction and suddent cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective  no –steroidal antiinflammatory drugs: Nested case-control study “  Lancet, febr, 5,2005,; 365.
  605. Lee BJ, Yen CH et al “ A significant correlation between the plasma levels of coenzyme Q 10 and vitamin B6 and a reduced risk of coronary artery disease” Nutr Res, 2012, oct; 32(10)
  606. Vikbladh I, “ Studies on zinc in blood “ Scand J Clin Lab Invest, 3 Supp 2; 1951.
  607. Mahabir S et al, Int J Cancer, 2006
  608. Sandstead HH, Frederickson CJ et al “ History of zinc as related to brain function”  J Nutr, 2000, febrero, 130(2S supp
  609. Sinha R “ National seminar on importance of zinc in human health “  Indian Pediatr, 2004, diciembre, 41(12)
  610. Fraker PJ, King LE et al “   The dinamic  link between  the integrity of the immune  system and zinc status  “  J Nutr, 2000, mayo, 130(5s sup)
  611. Fraker PJ King LE,  et al  Reprogramming of the immune system  durng zinc deficiency “ Annu Rev Nutr, 2004, 24)
  612. De Pascuale Jardieu P, Fraker PJ , , Immunology, 1980,124(6)
  613. Mittechell WA, Meng I et al “ Thymic output, aging and zinc “ Biogerontology, 2006, 9 septiembre
  614. LYM Y, Levy M et al “ Dietary zinc alters early inflammatory responses during cutaneous wound healing in weanling CD1 mice “  J Nuttr, 2004, abril, 134(4)
  615. Field CJ, Johnson IR et al “ Nutrients and their role in host resistance to infection “  J Leukoc Biol, 2002, enero, 71(1)
  616. Raqib R, Roy SK et al “ Effect of supplementation on  immune and inflammatory responses in pediatric patients with shigellosis “  Am J Clin Nutr,  2004, marzo,  79(3)
  617. Bogden JD et al “ Influences of zinc on immunity in the elderly” J Nutr Health Aging, 2004, 8(1)
  618. Chandra RK et al “ Impact of nutritional status and nutrient supplements on immune responses and incidence of infection in older individuals “ Ageing Res Rev ,2004, . enero, 3(1)
  619. Suara RO, Crowe JE et al. “ Efect of salts on Respiratory sybcytial virus replication”  Antimicrob Agents Chemother, 2004, marzo; 48(3)
  620. Kasperczyk S, Birkner E et al “  Activity of superoxide dismutase  and catalase in people protractedly exponed to lead compounds”  Ann Agric Environ Med, 2004, 11(2)
  621. KocaturkPA,Kavas GO et al “ Superoxide dismutase activity and zinc and copper concentrations in growth retardation “ Biol Trace Elem Res, 2004; 102(1-3)
  622. Landis GN , Tower J “ Superoxide dismutase evolution and life span regulation” Mech Ageing Dev, 2005, marzo 126(3)
  623. Kiefer D “ Superoxido dismutase:boosting the body´s primary antioxidant defense” Life Extension, junio 2006; 72)
  624. Yasuko Murakami, et al “ Zinc supplementation prevents the increase to transaminase in chronic hepatitis C patients during combination therapy with pegylated interferon alpha 2b and ribavirin” J Nutr Sci Vitaminol(Tokio) 2007, 53(3)
  625. Ames BN et al “ DNA damage from micronutrient deficiencias is likely to be a major cause for cancer “ Mutat Res, 2001, abril 18; 475(1-2)
  626. Linus Pauling Institute ,Universidad de Oregon y Chieldren´s Hospital Oajkland Research Institute, y la Universidad de California. American Journal of Clinical Nutrition,  agosto 2009), 90(2)
  627. Edwin van Wijngaarden, The Prostate; 15 de febrero 2008.
  628. Meydani SN, Barnett JB et al “ Serum zinc and pneumonia in nursing home elderly” Am J Clin Nutr, 2007; oct 86(4)Abdulhamid I, Beck FW,  et al “  Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis “  Pediatr Pulmonol , 2008; 43(3)
  629. Cabreiro F, Pericón M et al “ Zinc supplementation in the elderly subjects • Effects on oxidized protein degradation and repair systms in peripheral blood lymphocytes “  Exp Gerontology, 2008; 43(5)
  630. Ananda S.Prasad et al “ Zinc supplementation decreases incidence of infections in the elderly: Effect of zinc on generation of cyrokines and oxidative stress”  Am J Clin Nutr, 2007, mar85(3)
  631. Salgueiro MJ, WeillR et al “ Zinc deficiency and growth:current concepts in relationship to two importants points:intellectual and sexual development”  Biol Trace Elem Res, 2004; 99(1-3)
  632. Imamoglu S, Bereket A et al “ Effect of zinc supplementation on Growth hormone secretion, IGF-1, IGFBP-3,somatomedin generation,alkaline phospphatase,osteocalcin and Growth in prepubertal children with idiopathic short stature”   J Pediatr Endocrinolo Metab, 2005, enero; 18(1)
  633. Brown KH, Peerson JM et al Effect of supplemental zinc on the growth  and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials “   Am J Clin Nutr, 2002, junio, 75(6)
  634. Digirolamo AM, et a “ Randomized trial of the effect of zinc supplementation on the mental health of school-age children in Guatemala”  Am J  Clin Nutr, 2010, 29 septiembre.
  635. Kienast A, Roth B et al “ Zinc deficiency dermatitis in breast  fed infants “  Eur J pediatrc, 2006; 8 septiembre)
  636. Osendarp SJ, West CE et al “ The need for maternal zinc supplememntation in developing countries_: a unresolved issue “  J Nutr, 2003, marzo, 133(3)
  637. Makonnen B, Venter A et al “ A randomized controlled study of the impact  of dietary zinc supllementation in the management of children with protein energy malnutrition in Lesotho . I: Mortality and Morbidity “  J Trop Pediatr, 2003, diciembre, 49(6)
  638. Lukacik M, Thomas RL et al “ A meta análisis of the effects of oral zinc in the treatment of acute and persistent diarrhea “ Pediatrics, 2008, feb 121(2)
  639. Fischer TK, Viboud C et al “ Hospitalizations and deaths  from diarrhea and rotavirus among children < 5 years  of age in the United States, 1993-2003” J Infect Dis, 2007, apr 15; 195(8)
  640. Kosek M, Bern C et al “ The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000” Bull World Health Organ, 2003; 81(3)
  641. Parham M, Heidarian E et al “ Effects of zinc supplementation on microalbuminuria in patients with type 2 diabetes: a double blind, randomized, placebo  controlled , cross over trial “  Rev Diabet Stud, 2008, 5(2)
  642. Sun Q, Hu FB et al “ A prospective study of zinc intake  and risk of type 2 diabetes in women “  Diabetes Care, 2009, enero 26.
  643. Philpott M, Ferguson LR et al “ Immunonutrition and cancer “ Mutat Res, 2004, julio 13;  551(1-2)
  644. Gonzalez A, Peters U et al “ Zinc inatke from supplements and diet and prostet cancer “  Nutr Cancer, 2009, 61(2)
  645. Li-Ching Lin, et al “ Effects of zinc supplementation on clinical outcomens in patients receiving radiotherapy for head and neck carcers: a double blinded randomized Study”  Int J  Radiat Oncol Biol Phys, 2007; oct 31. )
  646. Sikora S, Apady D et al “ trace elements and vitamins at diagnosis in pediatric onset inflammatory bowel disease” Clin Pediatr ( Phila) 2011, 11 de febrero.
  647. Henkel R, Bittner J et al “ Relevance of zinc in human sperm flagela and its relation to motility “  Fertil Steril, 1999; junio, 71( 6)
  648. Chia SE, Ong CN et al “ Comparison of zinc concentrations in blood and  seminal plasma and the various sperm parameters between fertile and infertile men “  J Androl, 2000, 21(1)
  649. Lai J, Moxey A et al “ The eficacy of zinc supplementation in depression : systematic review of randomized  controlled trials” J Affect Disord, 2011, 26 de julio
  650. Lorscheider FL, Vimy MJ et al;”  Mercury exposure from “silver” tooth filing:emerging evidence questions a traditional dental paradigm”  FASEB,  1995, .9.504.
  651. PalkovicovaL, et al Maternal amalgam dental filling  as the source of mercury exposure in developing fetus and newborn “ J Expo  Sci  Environ  Epidemiol,” 2008,  mayo; 18(3)
  652. Lindh U. Removal of dental amalgam and other metal alloys supported by antioxidant therapy alleviates symptoms and improves quality of life in patients with amalgam-associated ill health. Neuroendocrinology Letters. 2002; 23(5/6):459-482.
  653. Ralston NV, Raymond LJ, “ Dietary selenium´s protective efects against methylmercury toxicity”  Toxicology;  2010, 28 de noviembre; 278( 1)
  654. Nutrition and cancer: A review of the evidence for an anti-cancer diet Michael S Donaldson Nutrition Journal 2004, 3:19
  655. European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Fahey M, Charrondière UR, Hémon B, Casagrande C, Vignat J, Overvad K, Tjønneland A, Clavel-Chapelon F, Thiébaut A, Wahrendorf J, Boeing H, Trichopoulos D, Trichopoulou A, Vineis P, Palli D, Bueno-De-Mesquita HB, Peeters PH, Lund E, Engeset D, González CA, Barricarte A, Berglund G, Hallmans G, Day NE, Key TJ, Kaaks R, Saracci R. Public Health Nutr. 2002 Dec;5(6B):1113-24.
  656. The European Prospective Investigation into Cancer and Nutrition biobank. Hainaut P, Vozar B, Rinaldi S, Riboli E, Caboux E. Methods Mol Biol. 2011;675:179-91. doi: 10.1007/978-1-59745-423-0_7.
  657. Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification.
  658. Menendez JA, Vellon L, Colomer R, Lupu R. Ann Oncol. 2005 Mar;16(3):359-71. Epub 2005 Jan 10.
  659. Inhibition of fatty acid synthase (FAS) suppresses HER2 neu(erbB-2) oncogene overexpressionin cancer cells. Javier A. Menendez, Luciano Vellon, Inderjit Mehmi*, Bharvi P. Oza*, Santiago Ropero, Ramon Colomer and Ruth Lupu. Department of Medicine, Evanston Northwestern Healthcare, 1001 University Place, Evanston, IL 60201; Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611;Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Center
  660. (CNIO), Melchor Fernandez Almagro 3, E-28029, Madrid, Spain; and Institut Catala d’Oncologia, Hospital Universitari Dr. Josep Trueta, Avinguda de Francas n, E-17007 Girona, Spain
  661. Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: Relationship to lipid peroxidation and HER-2/neu expression. Menendez JA, Ropero S, Lupu R, Colomer R. Oncol Rep. 2004 Jun;11(6):1241-52.
  662. Essential fatty acids in health and chronic disease. Simopoulos AP. Am J Clin Nutr. 1999 Sep;70(3 Suppl):560S-569S.
  663. Dietary fatty acids and the immune system P. C. Calder 1999, Volume 34, Issue 1 Supplement, pp S137-S140
  664. The role of docosahexaenoic acid in retinal function. Jeffrey BG, Weisinger HS, Neuringer M, Mitchell DC. Lipids. 2001 Sep;36(9):859-71
  665. Mechanisms of action of docosahexaenoic acid in the nervous system. Salem N Jr, Litman B, Kim HY, Gawrisch K. Lipids. 2001 Sep;36(9):945-59.
  666. Polyunsaturated fatty acids and cerebral function: focus on monoaminergic neurotransmission.
  667. Chalon S, Vancassel S, Zimmer L, Guilloteau D, Durand G. Lipids. 2001 Sep;36(9):937-44.
  668. Richardson AJ. La importancia de los ácidos grasos omega-3 en el comportamiento, cognición y estado de ánimo. Scandinavian Journal of Nutrition / Naringsforskning 2003; 47(2):92-8.
  669. Yehuda S, Rabinovitz S, Mostofsky DI. Los ácidos grasos esenciales son mediadores bioquímicos cerebrales y de las funciones cognitivas. Journal of Neuroscience Research 1999; 56(6):565-70
  670. Tamizi far, B. Tamizi. Tratamiento del síndrome de fatiga crónica mediante suplementos dietéticos con ácidos grasos w-3: Medical Hypotheses (2002) 58(3), 249-250
  671. Adel A.Zalata, Armand B.Christophe, Christophe E.Depuydt, Frank Schoonjans and Frank H.Comhaire. Composición en ácidos grasos de los fosfolípidos de los espermatozoos de pacientes infértiles. Molecular Human Reproduction vol.4 no.2 pp. 111–118, 1998
  672. Allen KG, Harris MA: Papel de los ácidos grasos omega 3 en la gestación y el parto. Exp Biol Med (Maywood). 2001 Jun;226(6):498-506
  673. John Colombo, Kathleen N. Kannass, D. Jill Shaddy, et al. DHA materno y desarrollo de la atención en la infancia. Child Development, 2004, 75, 4, 1254
  674. Ken D Stark and Bruce J Holub. Elevaciones diferenciales del ácido eicosapentaenoico y respuestas alteradas de factores de riesgo de enfermedad cardiovascular tras suplementos con DHA en mujeres postmenopausia que reciben o no tratamiento sustitutivo hormonal. Am J Clin Nutr 2004;79:765–73
  675. Campagnoli et al. Ácidos grasos poliinsaturados (PUFAs) pueden reducir los sofocos: indicación de dos ensayos controlados con isoflavonas de soja solas y con un suplemento de PUFA. Maturitas 51 (2005) 127–134
  676. Saldeen P, Saldeen T. La mujer y los ácidos grasos omega 3 Obstet Gynecol Surv. 2004 Oct;59(10):722-30; quiz 745
  677. Jacqueline Stordy. Adaptación a la oscuridad, habilidades motoras, ácido docosahexaenoico y dislexia. Am J Clin Nutr 2000;71(suppl):323S–6S.
  678. PA Gustafsson, K Duchen, U Birberg. Lactancia materna, PUFAs y cociente intellectual a los 6½años de edad. Acta Pædiatr 2004; 93: 1280–1287.
  679. “Acidos grasos Omega 3 y Enfermedad Cardiovascular: Recomendaciones científicas de la American Heart Asociation” Circulation 2002;106:2747-2757
  680. Oh Robert, Aplicaciones prácticas de los ácidos grasos omega 3 en atención primaria J Am Board Fam Pract 2005; 18: 28-36
  681. Morris MC, Evans DA, Bienias JL et al. Consumo de pescado y ácidos grasos n-3 y riesgo de incidencia de enfermedad de Alzheimer. Archives of Neurology 2003; 60(7):940-6.
  682. Janelle L. Cooper. Lípidos en la Dieta en la Etiologia de la enfermedad de Alzheimer. Implicaciones en el Tratamiento. Drugs Aging 2003; 20 (6): 399-418
  683. James M.J., Cleland L.G. Acidos grasos omega 3 en la dieta y tratamiento de la artritis reumatoidea. Semin Arthritis Rheum 1997, 27: 85-97
  684. Kremer J.L. Suplementos de ácidos grasos omega 3 en la artritis reumatoidea. Am J Clin Nutr 2000, 71 (suppl): 349S-51S
  685. Gogos C.A., Ginopoulos P., Salsa B., et al. Dietary Omega-3 Polyunsaturated Fatty Acids plus Vitamin E Restore Immunodeficiency and Prolong Survival for Severely Ill Patients with Generalized Malignancy. A Randomized Control Trial. Cancer 1998; 82:395–402Joanne Bradbury, Stephen P Myers and Chris Oliver. Papel adaptogénico de los ácidos grasos omega 3 en el estrés, estudio piloto intervencional aleatorizado doble ciego controlado con placebo. Nutrition Journal 2004, 3:20
  686. Freeman Marlene P. Los ácidos grasos Omega 3 en Psiquiatría: Revisión. Annals of Clinical Psychiatry, 2000, 12 (3): 159-165
  687. Stoll A.L., Severus W.E., Freeman M.E., et al. Acidos grasos omega 3 en transtorno bipolar. Arch Gen Psychiatry, 1999, 56: 407-412
  688. Rodriguez-Cruz M., Tovar A.R., Del Prado M., Torres N. Mecanismos moleculares de acción de los ácidos grasos poliinsaturados y sus beneficios en la salud. Rev Invest Clinica, 2005, 57 (3): 457-472
  689. SanGiovanni J.P., Chew E.Y. Papel de los ácidos grasos polinsaturados de cadena larga omega 3 en la salud y la enfermedad de la retina. Progress in Retinal and Eye Research 2005, 24: 87-139
  690. Positive outcomes for survivors of haematological malignancies from a spiritual perspective.
  691. McGrath P. Int J Nurs Pract. 2004 Dec;10(6):280-91.
  692. Spiritual expression and immune status in women with metastatic breast cancer: an exploratory study. Sephton SE, Koopman C, Schaal M, Thoresen C, Spiegel D.
  693. Breast J. 2001 Sep-Oct;7(5):345-53.
  694. Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients. Carlson LE, Speca M, Patel KD, Goodey E. Psychosom Med. 2003 Jul-Aug;65(4):571-81.
  695. Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma. Cohen L, Warneke C, Fouladi RT, Rodriguez MA, Chaoul-Reich A. 2004 May 15;100(10):2253-60
  696. Luff R, Ikkos D, Palmierl G, Ernster L & Afzelius B. A case of severe hypermetabolism ofnonthyroid origin with a defect in the maintenance of
  697. mitochondrial respiratory control: a correlated clinical, biochemical, and morphological study. J. C/in. Invest. 41:1776-804, 1962.
  698. Lyon G., Evrard PH. Neuropediatrie. Masson, Paris 1987
  699. Di Mauro S., Bonilla E. Zeviani M,. Nakagawa M., De VIVO D: Mitochondrial Myopathies. ARM
  700. Nisizawa M., Tanaka K., Schinozawa K, Et. Al A mitochondrial Encephalomyopathy with cardiomyopathy: The respiratory Chain. J Neurol SCI.

Este sitio web utiliza cookies para que usted tenga la mejor experiencia de usuario. Si continúa navegando está dando su consentimiento para la aceptación de las mencionadas cookies y la aceptación de nuestra política de cookies, pinche el enlace para mayor información.plugin cookies

Aviso de cookies